Pei-Xun Zhong1,2, Yi-Hsien Chen3, I-Hsun Li1,2,4, Yuan-Liang Wen5, Hui-Han Kao5,6,7, Kuan-Wei Chiang8, Li-Ting Kao9,10,11,12. 1. Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan. 2. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. 3. Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. 4. Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan. 5. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. 6. Science and Technology Policy Research and Information Center, National Applied Research Laboratories, Taipei, Taiwan. 7. School of Public Health, National Defense Medical Center, Taipei, Taiwan. 8. Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan. 9. Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan. kaoliting@gapps.ndmctsgh.edu.tw. 10. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. kaoliting@gapps.ndmctsgh.edu.tw. 11. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. kaoliting@gapps.ndmctsgh.edu.tw. 12. School of Public Health, National Defense Medical Center, Taipei, Taiwan. kaoliting@gapps.ndmctsgh.edu.tw.
Abstract
BACKGROUND: It is plausible that immunopathological processes associated with psoriasis might contribute to the occurrence of olfactory or taste dysfunction. However, the actual association was still unknown. PURPOSE: To determine the relationship between olfactory or taste dysfunction and psoriasis. METHODS: Two cross-sectional studies were performed by using National Health and Nutrition Examination Survey (NHANES) data. Participants with psoriasis were defined as cases and those without psoriasis were identified as controls. Taste and smell self-reported questionnaires were used to define smell/taste alterations and identification tests were used to assure the smell/taste dysfunctions. Logistic regression models with inverse probability treatment weighting (IPTW) strategies were conducted to investigated the relationship between psoriasis and olfactory or taste dysfunction. RESULTS: Self-reported questionnaires indicated that psoriasis patients were more likely to have perceived taste alteration (IPTW-aOR = 1.43) and smell alteration (IPTW-aOR = 1.22). Identification tests revealed that psoriasis was associated with taste dysfunction (IPTW-aOR = 1.28) and olfactory dysfunction (IPTW-aOR = 1.22). Relevant findings showed that psoriasis may be significantly associated with taste or olfactory dysfunction regardless of the questionnaire data or identification examination data used. CONCLUSION: Olfactory and taste dysfunction could be considered comorbidities in patients with psoriasis based on our observational study. Therefore, physicians should be cautious of olfaction and taste alterations among patients with psoriasis.
BACKGROUND: It is plausible that immunopathological processes associated with psoriasis might contribute to the occurrence of olfactory or taste dysfunction. However, the actual association was still unknown. PURPOSE: To determine the relationship between olfactory or taste dysfunction and psoriasis. METHODS: Two cross-sectional studies were performed by using National Health and Nutrition Examination Survey (NHANES) data. Participants with psoriasis were defined as cases and those without psoriasis were identified as controls. Taste and smell self-reported questionnaires were used to define smell/taste alterations and identification tests were used to assure the smell/taste dysfunctions. Logistic regression models with inverse probability treatment weighting (IPTW) strategies were conducted to investigated the relationship between psoriasis and olfactory or taste dysfunction. RESULTS: Self-reported questionnaires indicated that psoriasis patients were more likely to have perceived taste alteration (IPTW-aOR = 1.43) and smell alteration (IPTW-aOR = 1.22). Identification tests revealed that psoriasis was associated with taste dysfunction (IPTW-aOR = 1.28) and olfactory dysfunction (IPTW-aOR = 1.22). Relevant findings showed that psoriasis may be significantly associated with taste or olfactory dysfunction regardless of the questionnaire data or identification examination data used. CONCLUSION: Olfactory and taste dysfunction could be considered comorbidities in patients with psoriasis based on our observational study. Therefore, physicians should be cautious of olfaction and taste alterations among patients with psoriasis.
Authors: S Fonteyn; C Huart; N Deggouj; S Collet; P Eloy; P Rombaux Journal: Eur Ann Otorhinolaryngol Head Neck Dis Date: 2014-03-26 Impact factor: 2.080
Authors: Jayant M Pinto; Kristen E Wroblewski; David W Kern; L Philip Schumm; Martha K McClintock Journal: PLoS One Date: 2014-10-01 Impact factor: 3.240