Yi-Wei Huang1, Hui-Peng Huang2, Chao-Kai Hsu3, Julia Yu-Yun Lee3. 1. Dr. Yi-Wei Huang is with the Department of Dermatology at National Taiwan University Hospital in Taipei, Taiwan. 2. Dr. Hui-Peng Huang is with Huang Hui-Peng Dermatology Clinic in Tainan, Taiwan. 3. Drs. Hsu and Lee are with the Departments of Dermatology at National Cheng Kung University Hospital and College of Medicine in Taiwan.
Abstract
Background: Expression of inducible nitric oxide synthase (NOS) is higher in rosacea skin samples than in normal skin controls. Hydroxocobalamin is a potent inhibitor of all isoforms of NOS, capable of reducing the vasodilatations induced by nitric oxide. Objective: We aimed to evaluate the role of hydroxocobalamin in treating facial flushing and persistent erythema of rosacea. Methods: Thirteen patients with rosacea who displayed facial flushing and persistent erythema received 1 to 4 weekly intramuscular injections of hydroxocobalamin 1 to 2 mg. The outcomes were measured using the Clinician's Erythema Assessment (CEA) by photography and an infrared thermometer to evaluate the difference in skin surface temperature (SST) of the cheeks before and after treatment. Results: Thirty minutes after the first dose of intramuscular injection of hydroxocobalamin, the mean CEA significantly reduced from 2.2± 0.6 to 1.2±0.4 (p<0.001), and average SST also significantly reduced from 36.7±0.70°C to 36.2±0.61°C (p<0.001) on the cheeks. Conclusion: In our patient sample, intramuscular administration of hydroxocobalamin was effective for immediate reduction of facial erythema associated with rosacea.
Background: Expression of inducible nitric oxide synthase (NOS) is higher in rosacea skin samples than in normal skin controls. Hydroxocobalamin is a potent inhibitor of all isoforms of NOS, capable of reducing the vasodilatations induced by nitric oxide. Objective: We aimed to evaluate the role of hydroxocobalamin in treating facial flushing and persistent erythema of rosacea. Methods: Thirteen patients with rosacea who displayed facial flushing and persistent erythema received 1 to 4 weekly intramuscular injections of hydroxocobalamin 1 to 2 mg. The outcomes were measured using the Clinician's Erythema Assessment (CEA) by photography and an infrared thermometer to evaluate the difference in skin surface temperature (SST) of the cheeks before and after treatment. Results: Thirty minutes after the first dose of intramuscular injection of hydroxocobalamin, the mean CEA significantly reduced from 2.2± 0.6 to 1.2±0.4 (p<0.001), and average SST also significantly reduced from 36.7±0.70°C to 36.2±0.61°C (p<0.001) on the cheeks. Conclusion: In our patient sample, intramuscular administration of hydroxocobalamin was effective for immediate reduction of facial erythema associated with rosacea.
Authors: J Brice Weinberg; Youwei Chen; Ning Jiang; Bethany E Beasley; John C Salerno; Dipak K Ghosh Journal: Free Radic Biol Med Date: 2009-03-27 Impact factor: 7.376
Authors: Ana Karina Alves Moura; Fernanda Guedes; Maria Cecília Rivitti-Machado; Mirian N Sotto Journal: Arch Dermatol Res Date: 2018-01-12 Impact factor: 3.017