Development of sodium alginate/glycerol/tannic acid coated cotton as antimicrobial system.

Present study aims at developing antimicrobial cotton gauze by dip coating of sodium alginate (SA), glycerol (Gly) and tannic acid (TA) blend. SA blends were prepared with varying concentration of glycerol in the range of 10-40 %. Blended films were fabricated and characterized by Fourier transform-infrared (FTIR) spectroscopy, X-ray diffraction (XRD), tensile studies, and contact angle analysis. The mechanical behavior of films indicated significant decrease in the tensile strength and modulus with the increase in the glycerol content due to the plasticization effect. The hydrophilicity of the blend films increased with increase in the glycerol content. TA was added to the blend as an antimicrobial agent. These blends were coated on the cotton gauze by dip coating method and their characterizations were carried out by the scanning electron microscopy (SEM) which revealed a smooth coating of SA:Gly:TA blend on cotton gauze. Antimicrobial analysis of TA coated gauzes was carried out which showed >95 % viable colony reduction against E. coli and S. aureus. Cytocompatibility studies indicated excellent cell-compatible activity. These results implicated that such coated gauzes are promising candidate that hold the great potential to be utilized as infection-resistant material in the health care sector.