Jin Hua Zheng1,2,3, Jian Jun Ma4,5,6, Wen Hua Sun1,2, Zhi Dong Wang1,2, Qing Qing Chang1,2, Lin Rui Dong1,2, Xiao Xue Shi1,2, Ming Jian Li1,3. 1. Department of Neurology, Henan Provincial People's Hospital, 450003, Zhengzhou, Henan Province, China. 2. Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. 3. Department of Neurology, People's Hospital of Henan University, Henan Province, Zhengzhou, China. 4. Department of Neurology, Henan Provincial People's Hospital, 450003, Zhengzhou, Henan Province, China. majj1124@163.com. 5. Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. majj1124@163.com. 6. Department of Neurology, People's Hospital of Henan University, Henan Province, Zhengzhou, China. majj1124@163.com.
Abstract
PURPOSE: Excessive daytime sleepiness (EDS) is a common non-motor symptom in Parkinson's disease (PD), but its neuropathology remains elusive. Our goal is to explore the potential neural substrates of EDS in a large sample of individuals with PD. METHODS: We recruited 48 PD patients with and 87 PD patients without EDS. We used resting-state functional magnetic resonance imaging to compare amplitudes of low-frequency fluctuations (ALFF) between the two groups. We also explored functional connectivity (FC) between the entire brain and regions where ALFF differed between the two groups as well as FC between selected regions of interest. Age, Part III of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) score and use of dopamine receptor agonists were treated as covariates in the comparisons. RESULTS: EDS was associated with significantly lower ALFF in the left angular gyrus, and ALFF in this region correlated negatively with score on the Epworth Sleepiness Scale in patients with PD. EDS was also associated with significantly lower FC between the left angular gyrus and right cerebellum, based on seed-to-voxel and inter-ROI analyses. CONCLUSION: Our results suggest that EDS in PD patients is associated with reduced spontaneous neural activity in the left angular gyrus and with reduced FC between the left angular gyrus and cerebellum. These findings may help understand and treat EDS in PD.
PURPOSE: Excessive daytime sleepiness (EDS) is a common non-motor symptom in Parkinson's disease (PD), but its neuropathology remains elusive. Our goal is to explore the potential neural substrates of EDS in a large sample of individuals with PD. METHODS: We recruited 48 PD patients with and 87 PD patients without EDS. We used resting-state functional magnetic resonance imaging to compare amplitudes of low-frequency fluctuations (ALFF) between the two groups. We also explored functional connectivity (FC) between the entire brain and regions where ALFF differed between the two groups as well as FC between selected regions of interest. Age, Part III of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) score and use of dopamine receptor agonists were treated as covariates in the comparisons. RESULTS: EDS was associated with significantly lower ALFF in the left angular gyrus, and ALFF in this region correlated negatively with score on the Epworth Sleepiness Scale in patients with PD. EDS was also associated with significantly lower FC between the left angular gyrus and right cerebellum, based on seed-to-voxel and inter-ROI analyses. CONCLUSION: Our results suggest that EDS in PD patients is associated with reduced spontaneous neural activity in the left angular gyrus and with reduced FC between the left angular gyrus and cerebellum. These findings may help understand and treat EDS in PD.
Authors: Svenja Happe; Paul Christian Baier; Kathrin Helmschmied; Johannes Meller; Klaus Tatsch; Walter Paulus Journal: J Neurol Date: 2007-03-12 Impact factor: 4.849
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