| Literature DB >> 35768188 |
Vageesh Jain1, Jonathan Clarke2, Thomas Beaney3.
Abstract
BACKGROUND: Excess mortality has been used to assess the overall health impact of COVID-19 across countries. Democracies aim to build trust in government and enable checks and balances on decision making, which may be useful in a pandemic. But during the pandemic, they have been criticised as being hesitant to enforce restrictive public health measures.Entities:
Keywords: COVID-19; EPIDEMICS; HEALTH POLICY; MORTALITY
Year: 2022 PMID: 35768188 PMCID: PMC9271843 DOI: 10.1136/jech-2022-218920
Source DB: PubMed Journal: J Epidemiol Community Health ISSN: 0143-005X Impact factor: 6.286
Investigated factors, data sources and summary statistics
| Type | Domain | Variable | Period | Source (Reference) | Mean (SD) | Range |
| Outcome | Excess mortality | Excess mortality per 100 000 population | January 2020–September 2021 | World Mortality Database | 160 (146) | −41.7 to 608 |
| Exposure | Democratic governance | V-Dem Liberal Democracy Index (LDI) | 2019 | V-Dem Institute | 0.544 (0.257) | 0.062–0.858 |
| EIU Democracy Index | 2019 | EIU | 6.66 (1.98) | 1.94–9.81 | ||
| Covariates | Demographic | Population age ≥65(% total) | 2019 | World Bank | 14.3 (6.02) | 2.00–28.0 |
| Population age ≥80(% total) | 2019 | World Bank | 3.58 (1.98) | 0–8.56 | ||
| Population density (people per sq. km) | 2018 | World Bank | 321 (1153) | 2.04–7953.0 | ||
| Population female (%) | 2019 | World Bank | 50.3 (3.58) | 24.7–54.1 | ||
| Economic | GDP per capita (current US$) | 2019 | World Bank | 24 480 (23795) | 891–1 14 685 | |
| Gini index | 2014–2019 | World Bank | 34.5 (6.69) | 24.6–53.4 | ||
| COVID-19 burden | Cumulative COVID-19 cases per 100 000 population | Jan 2020- Sept 2021 | Johns Hopkins University | 5576 (3962) | 38.7–15 649 | |
| Chronic conditions | Prevalence of cardiovascular disease (%) | 2019 | Global Burden of Disease Study | 9.58 (3.48) | 3.47–16.5 | |
| Prevalence of chronic respiratory disease (%) | 2019 | Global Burden of Disease Study | 8.13 (3.28) | 3.11–16.1 | ||
| Prevalence of diabetes and kidney diseases (%) | 2019 | Global Burden of Disease Study | 16.4 (3.53) | 8.94–25.4 | ||
| Prevalence of neurological disorders (%) | 2019 | Global Burden of Disease Study | 41.2 (4.73) | 28.4–50.9 | ||
| Prevalence of cancer (%) | 2019 | Global Burden of Disease Study | 11.9 (5.05) | 3.77–27.0 | ||
| Disease risk factors | Prevalence of adult obesity (BMI >30, %) | 2010–2019 | World Obesity Federation | 20.8 (7.97) | 3.60–42.7 | |
| Age-standardised mortality rate attributed to household and ambient air pollution per 100 000 population | 2016 | World Health Statistics 2020 | 42.7 (34.9) | 5.90–185.2 | ||
| Age standardised prevalence of tobacco smoking among persons aged 15 and older (%) | 2018 | World Health Statistics 2020 | 24.0 (8.54) | 6.90–44.7 | ||
| Health system | UHC Service Coverage Index | 2017 | World Bank | 75.2 (7.63) | 55.0–89.0 | |
| Current health expenditure per capita (current US$) | 2018 | World Bank | 2088 (22397) | 59.8–10 623 | ||
| Out-of-pocket expenditure (% current health expenditure) | 2018 | World Bank | 29.2 (16.5) | 5.99–84.3 | ||
| Vaccination | Population in receipt of at least one dose of COVID-19 vaccine (%) | Jan 2020 - August 2021 | Our World in Data | 43.0 (22.3) | 3.63–78.4 | |
| Proportion fully vaccinated against COVID-19 (%) | Jan 2020 - August 2021 | Our World in Data | 32.5 (21.7) | 0.58–74.4 | ||
| Strength of restrictive policies | COVID-19 Stringency Index | Time of 1000th Case | Oxford COVID-19 Government Response Tracker | 75 (22.8) | 11.1–100 |
BMI, body mass index; EIU, Economist Intelligence Unit; GDP, gross domestic product; UHC, Universal Health Coverage.
Univariable linear regression of factors associated with excess mortality per 100 000 for all countries
| Variable | Change in excess mortality per 100 000 for one-unit change in variable | P value | 95% CI |
| V-Dem Liberal Democracy Index (LDI) | −1.50 | 0.016 | −2.71 to −0.29 |
| EIU Democracy Index | −20.3 | 0.009 | −35.5 to −5.15 |
| Age ≥65 years (%) | 4.37 | 0.60 | −0.99 to 9.73 |
| Age ≥80 years (%) | 10.2 | 0.21 | −5.84 to 26.3 |
| Log population density (ppl/sqm) | −13.5 | 0.22 | −35.2 to 8.23 |
| Population female (%) | 8.80 | 0.04 | 0.47 to 17.1 |
| GDP per capita (current US $) | −0.002 | <0.001 | −0.004 to −0.001 |
| Gini index | 1.85 | 0.49 | −3.49 to 7.18 |
| Cumulative COVID-19 cases | 0.01 | 0.002 | 0.005 to 0.02 |
| Prevalence of cardiovascular disease (%) | 16.2 | 0.001 | 7.18 to 25.2 |
| Prevalence of chronic respiratory disease (%) | −5.83 | 0.23 | −15.4 to 3.77 |
| Prevalence of diabetes and kidney diseases (%) | 8.58 | 0.08 | −0.97 to 18.1 |
| Prevalence of neurological disorders (%) | 5.02 | 0.20 | −2.75 to 12.8 |
| Prevalence of cancer (%) | 7.28 | 0.02 | 1.19 to 13.4 |
| Prevalence of adult obesity (BMI >30, %) | 0.69 | 0.33 | −3.45 to 4.83 |
| Age-standardised mortality rate attributed to household and ambient air pollution per 100 000 population | 0.70 | 0.13 | −0.22 to 1.62 |
| Age standardised prevalence of tobacco smoking among persons aged 15 and older (%) | 5.81 | 0.003 | 2.07 to 9.56 |
| UHC Service Index | −4.98 | 0.02 | −8.95 to −1.02 |
| Current health expenditure per capita (US$) | −0.02 | 0.003 | −0.03 to −0.007 |
| Out-of-pocket expenditure (% current health expenditure) | 2.12 | 0.03 | 0.24 to 3.99 |
| Population in receipt of at least one dose of COVID-19 vaccine (%) | −1.92 | 0.006 | −3.26 to −0.58 |
| Proportion fully vaccinated against COVID-19 (%) | −1.13 | 0.12 | −2.57 to 0.30 |
| Stringency Index (at 1000th case) | 0.95 | 0.17 | −0.41 to 0.23 |
BMI, body mass index; EIU, Economist Intelligence Unit; GDP, gross domestic product; UHC, Universal Health Coverage.
Figure 1Maps showing the World Bank income classification (A), excess mortality per 100 000 people (B) and V-Dem Liberal Democracy Index (C) of included countries.
Figure 2Excess mortality per 100 000 population and V-Dem Liberal Democracy Index across all included countries.
Association between V-Dem Liberal Democracy Index and excess mortality per 100 000 population (n=75)
| Variable | Change in excess mortality per 100 000 for one-unit change in variable | P value | 95% CI |
| V-Dem Liberal Democracy Index (LDI) | −2.18 | 0.004 | −3.64 to −0.72 |
| Age ≥65 years (%) | 13.3 | <0.001 | 7.19 to 19.4 |
| Population female (%) | 3.31 | 0.46 | −5.65 to 12.3 |
| GDP per capita (current US$) | −0.001 | 0.15 | −0.003 to 0.0005 |
| UHC Service Coverage Index | −3.87 | 0.11 | −8.70 to 0.96 |
R2=0.39.
GDP, gross domestic product; UHC, Universal Health Coverage.
Association between V-DEM component indices and excess mortality per 100 000 population* (n=75)
| Alternative V-DEM component indices | Change in excess mortality per 100 000 for one-unit change in index | P value | 95% CI |
| Electoral | −0.95 | 0.22 | −2.47 to 0.57 |
| Liberal | −0.94 | 0.24 | −2.51 to 0.63 |
| Egalitarian | −1.78 | 0.08 | −3.78 to 0.21 |
| Participatory | 0.22 | 0.82 | −1.76 to 2.21 |
| Deliberative | −1.60 | 0.02 | −2.94 to −0.27 |
*All models adjusted for age ≥65 years, population female, GDP per capita and UHC Index.
GDP, gross domestic product; UHC, Universal Health Coverage; V-DEM, Varieties of Democracy.