| Literature DB >> 35767192 |
Xin Li1, Xinyu Su2, Chen Yan1, Yuanyuan Ma1, Heng Li1, Jianhong Xia1, Hongliang Li1, Qian Jiang1, Liqing Zhou3, Zhengyun Zou4,5,6.
Abstract
Vascular endothelial growth factor (VEGF) is related to the radiation resistance of tumors, resulting in the failure of tumor radiotherapy. The purpose of this study was to discuss the role of VEGF in radiotherapy resistance of esophageal squamous cell carcinoma (ESCC). We used the VEGF kit by ELISA to detect the serum VEGF level of ESCC patients who only received radiotherapy. The expression of VEGF in ESCC cells after siRNA treatment was verified by Western blot. The sensitivity of ESCC cells to radiation after knocking down VEGF was analyzed by Clonogenic assay and Cell counting kit (CCK-8). The results showed that the level of serum VEGF in patients with ESCC before and after radiotherapy was related to the clinical response, and it was confirmed that knocking down the expression of VEGF in ESCC cells improved the sensitivity to radiation.Entities:
Keywords: Anti-angiogenesis; Curative effect; Esophageal carcinoma; Radiotherapy; Vascular endothelial growth factor
Year: 2022 PMID： 35767192 DOI： 10.1007/s00432-022-04122-x
Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553