Kara DiJoseph1, Audrey Thorp1, Alex Harrington2, Kathryn H Schmitz3,4,5,6, Vernon M Chinchilli3, Jonathan G Stine7,8,9,10. 1. Department of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA, USA. 2. College of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA, USA. 3. Department of Public Health Sciences, The Pennsylvania State University- College of Medicine, Hershey, PA, USA. 4. Cancer Institute, The Pennsylvania State University- Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA. 5. Department of Kinesiology, The Pennsylvania State University- College of Health and Human Development, University Park, PA, USA. 6. Department of Physical Medicine & Rehabilitation, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA, USA. 7. Department of Public Health Sciences, The Pennsylvania State University- College of Medicine, Hershey, PA, USA. jstine@pennstatehealth.psu.edu. 8. Cancer Institute, The Pennsylvania State University- Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA. jstine@pennstatehealth.psu.edu. 9. Division of Gastroenterology and Hepatology, Department of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA, USA. jstine@pennstatehealth.psu.edu. 10. Liver Center, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA, USA. jstine@pennstatehealth.psu.edu.
Abstract
BACKGROUND & AIMS: Physical activity offers promise to protect against multiple non-hepatic primary cancers. We performed a systematic review to quantify the association between physical activity and hepatocellular carcinoma (HCC) risk. METHODS: We searched the Cochrane Library, Embase, Medline and trial registries through December 2020 for studies that measured physical activity levels in adults at risk for HCC. The primary outcome was HCC. Subgroup analysis was performed limiting to vigorous physical activity. Proportions and random-effects odds ratios (OR) with corresponding 95% confidence intervals (CI) were calculated. RESULTS: Seven studies met inclusion criteria, comprising 777,662 subjects (median age 55 years; 55% female). Greater amounts of physical activity were associated with less HCC (OR 0.65, 95% CI 0.45-0.95, p = 0.03) compared to lower amounts. Vigorous physical activity was associated with even less HCC (OR 0.62, 95% CI 0.49-0.79, p < 0.01). CONCLUSIONS: This meta-analysis demonstrates that greater amounts of physical activity are associated with lower odds of HCC. These results support the use of regular physical activity as an effective way to prevent HCC and provide helpful data to support a for future exercise-based interventional study to better define the optimal exercise prescription for patients at risk for primary liver cancer.
BACKGROUND & AIMS: Physical activity offers promise to protect against multiple non-hepatic primary cancers. We performed a systematic review to quantify the association between physical activity and hepatocellular carcinoma (HCC) risk. METHODS: We searched the Cochrane Library, Embase, Medline and trial registries through December 2020 for studies that measured physical activity levels in adults at risk for HCC. The primary outcome was HCC. Subgroup analysis was performed limiting to vigorous physical activity. Proportions and random-effects odds ratios (OR) with corresponding 95% confidence intervals (CI) were calculated. RESULTS: Seven studies met inclusion criteria, comprising 777,662 subjects (median age 55 years; 55% female). Greater amounts of physical activity were associated with less HCC (OR 0.65, 95% CI 0.45-0.95, p = 0.03) compared to lower amounts. Vigorous physical activity was associated with even less HCC (OR 0.62, 95% CI 0.49-0.79, p < 0.01). CONCLUSIONS: This meta-analysis demonstrates that greater amounts of physical activity are associated with lower odds of HCC. These results support the use of regular physical activity as an effective way to prevent HCC and provide helpful data to support a for future exercise-based interventional study to better define the optimal exercise prescription for patients at risk for primary liver cancer.
Authors: Mohammad Hassan Murad; Victor M Montori; John P A Ioannidis; Roman Jaeschke; P J Devereaux; Kameshwar Prasad; Ignacio Neumann; Alonso Carrasco-Labra; Thomas Agoritsas; Rose Hatala; Maureen O Meade; Peter Wyer; Deborah J Cook; Gordon Guyatt Journal: JAMA Date: 2014-07 Impact factor: 56.272
Authors: Brian Hutton; Georgia Salanti; Deborah M Caldwell; Anna Chaimani; Christopher H Schmid; Chris Cameron; John P A Ioannidis; Sharon Straus; Kristian Thorlund; Jeroen P Jansen; Cynthia Mulrow; Ferrán Catalá-López; Peter C Gøtzsche; Kay Dickersin; Isabelle Boutron; Douglas G Altman; David Moher Journal: Ann Intern Med Date: 2015-06-02 Impact factor: 25.391