Yanghanzhao Wang1,2, Mengdi Qu1,2, Zhiyun Qiu1,2, Shuainan Zhu1,2, Wankun Chen1,2, Kefang Guo3,4, Changhong Miao5,6,7, Hao Zhang8,9. 1. Department of Anesthesiology, Zhongshan Hospital, Fudan University, 180# Feng-Lin Road, Shanghai, 200032, China. 2. Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. 3. Department of Anesthesiology, Zhongshan Hospital, Fudan University, 180# Feng-Lin Road, Shanghai, 200032, China. guo.kefang@zs-hospital.sh.cn. 4. Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. guo.kefang@zs-hospital.sh.cn. 5. Department of Anesthesiology, Zhongshan Hospital, Fudan University, 180# Feng-Lin Road, Shanghai, 200032, China. miaochangh@163.com. 6. Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. miaochangh@163.com. 7. Department of Anesthesiology, Fudan University Jinshan Hospital, Shanghai, China. miaochangh@163.com. 8. Department of Anesthesiology, Zhongshan Hospital, Fudan University, 180# Feng-Lin Road, Shanghai, 200032, China. eliteromes@126.com. 9. Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. eliteromes@126.com.
Abstract
PURPOSE OF REVIEW: The stress response to surgery is essential for maintaining homeostasis and exhibits anti-tumor effects; however, an ongoing and exaggerated stress response may have adverse clinical consequences and even promote cancer progression. This review will discuss the complex relationship between surgical stress and cancer progression. RECENT FINDINGS: Surgical stress exhibits both anti-tumor and cancer-promoting effects by causing changes in the neuroendocrine, circulatory, and immune systems. Many studies have found that many mechanisms are involved in the process, and the corresponding targets could be applied for cancer therapy. Although surgical stress may have anti-tumor effects, it is necessary to inhibit an excessive stress response, mostly showing cancer-promoting effects.
PURPOSE OF REVIEW: The stress response to surgery is essential for maintaining homeostasis and exhibits anti-tumor effects; however, an ongoing and exaggerated stress response may have adverse clinical consequences and even promote cancer progression. This review will discuss the complex relationship between surgical stress and cancer progression. RECENT FINDINGS: Surgical stress exhibits both anti-tumor and cancer-promoting effects by causing changes in the neuroendocrine, circulatory, and immune systems. Many studies have found that many mechanisms are involved in the process, and the corresponding targets could be applied for cancer therapy. Although surgical stress may have anti-tumor effects, it is necessary to inhibit an excessive stress response, mostly showing cancer-promoting effects.