Yifrah Kaminer1, Grace Chan1, Rebecca Burke1. 1. Department of Pyschiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Abstract
BACKGROUND AND OBJECTIVES: Recruitment challenges for treatment trials of adolescents with substance use disorder (SUD) and co-occurring depression (COD) have not been reported. The objective is to examine whether recruitment and engagement during the pretreatment assessment phase differ between adolescents in a SUD-COD versus SUD-only treatment study. METHODS: A similar recruitment approach compared five-stage progressions in the pretreatment phase between a SUD-only (n = 252) and SUD-COD (n = 212) study. We examined the "gradient" of recruitment and retention along four stages after referral/inquiries; (a) screening for eligibility by phone, (b) meeting eligibility in an interview, (c) completion of baseline assessment, and (d) participation in the first psychotherapy session of each study. RESULTS: Compared to SUD-only, the retention of adolescents with SUD-COD was significantly poorer from referral/inquiry to all subsequent stages. In particular, the odds ratio and 95% confidence interval from referral/inquiry to screening for eligibility by phone, meeting eligibility in an interview, completion of baseline assessment, and participation in the first psychotherapy session were all less than one. Male attrition rates were slightly higher than females but were not statistically significant. DISCUSSION AND CONCLUSIONS: A high proportion of referred adolescents did not meet the study criteria. This indicates a need to examine (1) potential strategies for overcoming recruitment challenges in adolescents and their engagement in the pretreatment phase for studies of COD and (2) baseline variables for predictors and moderators for adequately powered studies. SCIENTIFIC SIGNIFICANCE: This is the first study to assess recruitment challenges for adolescents with COD.
BACKGROUND AND OBJECTIVES: Recruitment challenges for treatment trials of adolescents with substance use disorder (SUD) and co-occurring depression (COD) have not been reported. The objective is to examine whether recruitment and engagement during the pretreatment assessment phase differ between adolescents in a SUD-COD versus SUD-only treatment study. METHODS: A similar recruitment approach compared five-stage progressions in the pretreatment phase between a SUD-only (n = 252) and SUD-COD (n = 212) study. We examined the "gradient" of recruitment and retention along four stages after referral/inquiries; (a) screening for eligibility by phone, (b) meeting eligibility in an interview, (c) completion of baseline assessment, and (d) participation in the first psychotherapy session of each study. RESULTS: Compared to SUD-only, the retention of adolescents with SUD-COD was significantly poorer from referral/inquiry to all subsequent stages. In particular, the odds ratio and 95% confidence interval from referral/inquiry to screening for eligibility by phone, meeting eligibility in an interview, completion of baseline assessment, and participation in the first psychotherapy session were all less than one. Male attrition rates were slightly higher than females but were not statistically significant. DISCUSSION AND CONCLUSIONS: A high proportion of referred adolescents did not meet the study criteria. This indicates a need to examine (1) potential strategies for overcoming recruitment challenges in adolescents and their engagement in the pretreatment phase for studies of COD and (2) baseline variables for predictors and moderators for adequately powered studies. SCIENTIFIC SIGNIFICANCE: This is the first study to assess recruitment challenges for adolescents with COD.
Authors: Stephen P Hinshaw; Kimberly Hoagwood; Peter S Jensen; Christopher Kratochvil; Leonard Bickman; Greg Clarke; Howard B Abikoff; Marc Atkins; Benedetto Vitiello Journal: J Am Acad Child Adolesc Psychiatry Date: 2004-08 Impact factor: 8.829
Authors: Diane E May; Mary J Hallin; Christopher J Kratochvil; Susan E Puumala; Lynette S Smith; Mark A Reinecke; Susan G Silva; Elizabeth B Weller; Benedetto Vitiello; Alfiee Breland-Noble; John S March Journal: J Am Acad Child Adolesc Psychiatry Date: 2007-07 Impact factor: 8.829
Authors: Maria E Loades; Lucie Smith; Nina Higson-Sweeney; Lucy Beasant; Paul Stallard; David Kessler; Esther Crawley Journal: BMC Med Res Methodol Date: 2019-04-27 Impact factor: 4.615