| Literature DB >> 3576201 |
J F Flood, G E Smith, J E Morley.
Abstract
Allowing mice access to food immediately after an aversive training session enhances memory retention. Cholecystokinin-octapeptide (CCK-8), which is a gastrointestinal hormone released during feeding, also enhances memory retention when administered intraperitoneally. This memory-enhancing effect of CCK-8 is blocked when the vagus nerve is cut, indicating that CCK-8 may produce its effect on memory retention by activating ascending fibers in the vagus nerve. Thus, CCK-8, a peripherally acting peptide, may mediate the memory-enhancing effects of feeding.Entities:
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Year: 1987 PMID： 3576201 DOI： 10.1126/science.3576201
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728