Literature DB >> 35761047

Preparation of Site-Specific Succinylated Histone Mimics to Investigate Its Impact on Nucleosome Dynamics.

Yihang Jing1, Zheng Liu1, Xiang David Li2.   

Abstract

Posttranslational modifications (PTMs) of histones have been demonstrated to be the key regulating mechanism of nucleosome dynamics and chromatin structure. Lysine succinylation is a recently discovered PTM that plays critical roles in metabolism, epigenetic signaling, and is correlated with several diseases. One significant challenge in studying the effects of this modification on nucleosome dynamics is to obtain site-specifically modified histones. Here, we report the rapid site-specific incorporation of a succinylation mimic into histones, which facilitates the characterization of its impact on nucleosome dynamics with a Förster resonance energy transfer (FRET) approach.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Chromatin structure; Histone succinylation; Nucleosome dynamics; Protein chemistry; Protein labeling

Mesh：

Substances：

Year:  2022        PMID： 35761047     DOI： 10.1007/978-1-0716-2489-0_10

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  16 in total

Review 1.  Single-pair FRET experiments on nucleosome conformational dynamics.

Authors:  Ruth Buning; John van Noort
Journal:  Biochimie       Date:  2010-08-25       Impact factor: 4.079

2.  Mild metabolic perturbations alter succinylation of mitochondrial proteins.

Authors:  Huanlian Chen; Hui Xu; Samuel Potash; Anatoly Starkov; Vsevolod V Belousov; Dmitry S Bilan; Travis T Denton; Gary E Gibson
Journal:  J Neurosci Res       Date:  2017-06-20       Impact factor: 4.164

3.  A direct method for site-specific protein acetylation.

Authors:  Fupeng Li; Abdollah Allahverdi; Renliang Yang; Gavian Bing Jia Lua; Xiaohong Zhang; Yuan Cao; Nikolay Korolev; Lars Nordenskiöld; Chuan-Fa Liu
Journal:  Angew Chem Int Ed Engl       Date:  2011-09-16       Impact factor: 15.336

4.  New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning.

Authors:  P T Lowary; J Widom
Journal:  J Mol Biol       Date:  1998-02-13       Impact factor: 5.469

Review 5.  Histones: at the crossroads of peptide and protein chemistry.

Authors:  Manuel M Müller; Tom W Muir
Journal:  Chem Rev       Date:  2014-10-20       Impact factor: 60.622

6.  SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

Authors:  Jeongsoon Park; Yue Chen; Daniel X Tishkoff; Chao Peng; Minjia Tan; Lunzhai Dai; Zhongyu Xie; Yi Zhang; Bernadette M M Zwaans; Mary E Skinner; David B Lombard; Yingming Zhao
Journal:  Mol Cell       Date:  2013-06-27       Impact factor: 17.970

Review 7.  Chemical Protein Modification through Cysteine.

Authors:  Smita B Gunnoo; Annemieke Madder
Journal:  Chembiochem       Date:  2016-03-09       Impact factor: 3.164

8.  The site-specific installation of methyl-lysine analogs into recombinant histones.

Authors:  Matthew D Simon; Feixia Chu; Lisa R Racki; Cecile C de la Cruz; Alma L Burlingame; Barbara Panning; Geeta J Narlikar; Kevan M Shokat
Journal:  Cell       Date:  2007-03-09       Impact factor: 41.582

Review 9.  Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins.

Authors:  Kathrin Lang; Jason W Chin
Journal:  Chem Rev       Date:  2014-03-21       Impact factor: 60.622

10.  NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance.

Authors:  Feng Li; Xiadi He; Dingwei Ye; Yan Lin; Hongxiu Yu; Cuifang Yao; Lei Huang; Jianong Zhang; Fang Wang; Sha Xu; Xiaohui Wu; Lixia Liu; Chen Yang; Jiaqi Shi; Xiaoyang He; Jie Liu; Yuanyuan Qu; Fushen Guo; Jianyuan Zhao; Wei Xu; Shimin Zhao
Journal:  Mol Cell       Date:  2015-11-12       Impact factor: 19.328
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