| Literature DB >> 35760913 |
Yongqin Liu1,2,3, Mukan Ji4, Tao Yu5,6, Julian Zaugg7, Alexandre M Anesio8, Zhihao Zhang9,5, Songnian Hu5,6, Philip Hugenholtz7, Keshao Liu9, Pengfei Liu4, Yuying Chen9,5, Yingfeng Luo10,11, Tandong Yao9.
Abstract
Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-latitude glaciers and is particularly vulnerable to global warming. By sequencing 85 metagenomes and 883 cultured isolates from 21 Tibetan glaciers covering snow, ice and cryoconite habitats, we present a specialized glacier microbial genome and gene catalog to archive glacial genomic and functional diversity. This comprehensive Tibetan Glacier Genome and Gene (TG2G) catalog includes 883 genomes and 2,358 metagenome-assembled genomes, which represent 968 candidate species spanning 30 phyla. The catalog also contains over 25 million non-redundant protein-encoding genes, the utility of which is demonstrated by the exploration of secondary metabolite biosynthetic potentials, virulence factor identification and global glacier metagenome comparison. The TG2G catalog is a valuable resource that enables enhanced understanding of the structure and functions of Tibetan glacial microbiomes.Entities:
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Year: 2022 PMID： 35760913 DOI： 10.1038/s41587-022-01367-2
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 68.164