Reno C Leeming1, Stella Koutros2, Margaret R Karagas1, Dalsu Baris2, Molly Schwenn3, Alison Johnson4, Michael S Zens1, Alan R Schned5, Nathaniel Rothman2, Debra T Silverman2, Michael N Passarelli6. 1. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, HB 7927, Hanover, Lebanon, NH, 03756, USA. 2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA. 3. Maine Cancer Registry, Augusta, ME, USA. 4. Vermont Department of Health, Burlington, VT, USA. 5. Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. 6. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, HB 7927, Hanover, Lebanon, NH, 03756, USA. michael.n.passarelli@dartmouth.edu.
Abstract
PURPOSE: We examined the interaction between common genetic bladder cancer variants, diet quality, and bladder cancer risk in a population-based case-control study conducted in New England. METHODS: At the time of enrollment, 806 bladder cancer cases and 974 controls provided a DNA sample and completed a diet history questionnaire. Diet quality was assessed using the 2010 Alternate Healthy Eating Index (AHEI-2010) score. Single nucleotide polymorphisms (SNPs) reported in genome-wide association studies to be associated with bladder cancer risk were combined into a polygenic risk score and also examined individually for interaction with the AHEI-2010. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression. RESULTS: A 1-standard deviation increase in polygenic risk score was associated with higher bladder cancer risk (OR, 1.34; 95% CI 1.21-1.49). Adherence to the AHEI-2010 was not associated with bladder cancer risk (OR, 0.99; 95% CI 0.98-1.00) and the polygenic risk score did not appear to modify the association between the AHEI-2010 and bladder cancer risk. In single-SNP analyses, rs8102137 (bladder cancer risk allele, C) modified the association between the AHEI-2010 total score and bladder cancer risk, with the strongest evidence for the AHEI-2010 long chain fat guideline (OR for TT, 0.92; 95% CI 0.87-0.98; OR for CT, 1.02; 95% CI 0.96-1.08; OR for CC, 1.03; 95% CI 0.93-1.14; p for interaction, 0.02). CONCLUSIONS: In conclusion, rs8102137 near the cyclin E1 gene ( CCNE1 ) may be involved in gene-diet interactions for bladder cancer risk.
PURPOSE: We examined the interaction between common genetic bladder cancer variants, diet quality, and bladder cancer risk in a population-based case-control study conducted in New England. METHODS: At the time of enrollment, 806 bladder cancer cases and 974 controls provided a DNA sample and completed a diet history questionnaire. Diet quality was assessed using the 2010 Alternate Healthy Eating Index (AHEI-2010) score. Single nucleotide polymorphisms (SNPs) reported in genome-wide association studies to be associated with bladder cancer risk were combined into a polygenic risk score and also examined individually for interaction with the AHEI-2010. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression. RESULTS: A 1-standard deviation increase in polygenic risk score was associated with higher bladder cancer risk (OR, 1.34; 95% CI 1.21-1.49). Adherence to the AHEI-2010 was not associated with bladder cancer risk (OR, 0.99; 95% CI 0.98-1.00) and the polygenic risk score did not appear to modify the association between the AHEI-2010 and bladder cancer risk. In single-SNP analyses, rs8102137 (bladder cancer risk allele, C) modified the association between the AHEI-2010 total score and bladder cancer risk, with the strongest evidence for the AHEI-2010 long chain fat guideline (OR for TT, 0.92; 95% CI 0.87-0.98; OR for CT, 1.02; 95% CI 0.96-1.08; OR for CC, 1.03; 95% CI 0.93-1.14; p for interaction, 0.02). CONCLUSIONS: In conclusion, rs8102137 near the cyclin E1 gene ( CCNE1 ) may be involved in gene-diet interactions for bladder cancer risk.
Authors: L E Moore; D R Baris; J D Figueroa; M Garcia-Closas; M R Karagas; M R Schwenn; A T Johnson; J H Lubin; D W Hein; C L Dagnall; J S Colt; M Kida; M A Jones; A R Schned; S S Cherala; S J Chanock; K P Cantor; D T Silverman; N Rothman Journal: Carcinogenesis Date: 2010-10-29 Impact factor: 4.944
Authors: Lambertus A Kiemeney; Patrick Sulem; Soren Besenbacher; Sita H Vermeulen; Asgeir Sigurdsson; Gudmar Thorleifsson; Daniel F Gudbjartsson; Simon N Stacey; Julius Gudmundsson; Carlo Zanon; Jelena Kostic; Gisli Masson; Hjordis Bjarnason; Stefan T Palsson; Oskar B Skarphedinsson; Sigurjon A Gudjonsson; J Alfred Witjes; Anne J Grotenhuis; Gerald W Verhaegh; D Timothy Bishop; Sei Chung Sak; Ananya Choudhury; Faye Elliott; Jennifer H Barrett; Carolyn D Hurst; Petra J de Verdier; Charlotta Ryk; Peter Rudnai; Eugene Gurzau; Kvetoslava Koppova; Paolo Vineis; Silvia Polidoro; Simonetta Guarrera; Carlotta Sacerdote; Marcello Campagna; Donatella Placidi; Cecilia Arici; Maurice P Zeegers; Eliane Kellen; Berta Saez Gutierrez; José I Sanz-Velez; Manuel Sanchez-Zalabardo; Gabriel Valdivia; Maria D Garcia-Prats; Jan G Hengstler; Meinolf Blaszkewicz; Holger Dietrich; Roel A Ophoff; Leonard H van den Berg; Kristin Alexiusdottir; Kristleifur Kristjansson; Gudmundur Geirsson; Sigfus Nikulasson; Vigdis Petursdottir; Augustine Kong; Thorgeir Thorgeirsson; N Aydin Mungan; Annika Lindblom; Michael A van Es; Stefano Porru; Frank Buntinx; Klaus Golka; José I Mayordomo; Rajiv Kumar; Giuseppe Matullo; Gunnar Steineck; Anne E Kiltie; Katja K H Aben; Eirikur Jonsson; Unnur Thorsteinsdottir; Margaret A Knowles; Thorunn Rafnar; Kari Stefansson Journal: Nat Genet Date: 2010-03-28 Impact factor: 38.330
Authors: Montserrat Garcia-Closas; Yuanqing Ye; Nathaniel Rothman; Jonine D Figueroa; Núria Malats; Colin P Dinney; Nilanjan Chatterjee; Ludmila Prokunina-Olsson; Zhaoming Wang; Jie Lin; Francisco X Real; Kevin B Jacobs; Dalsu Baris; Michael Thun; Immaculata De Vivo; Demetrius Albanes; Mark P Purdue; Manolis Kogevinas; Ashish M Kamat; Seth P Lerner; H Barton Grossman; Jian Gu; Xia Pu; Amy Hutchinson; Yi-Ping Fu; Laurie Burdett; Meredith Yeager; Wei Tang; Adonina Tardón; Consol Serra; Alfredo Carrato; Reina García-Closas; Josep Lloreta; Alison Johnson; Molly Schwenn; Margaret R Karagas; Alan Schned; Gerald Andriole; Robert Grubb; Amanda Black; Eric J Jacobs; W Ryan Diver; Susan M Gapstur; Stephanie J Weinstein; Jarmo Virtamo; David J Hunter; Neil Caporaso; Maria Teresa Landi; Joseph F Fraumeni; Debra T Silverman; Stephen J Chanock; Xifeng Wu Journal: Hum Mol Genet Date: 2011-08-08 Impact factor: 6.150
Authors: Lambertus A Kiemeney; Steinunn Thorlacius; Patrick Sulem; Frank Geller; Katja K H Aben; Simon N Stacey; Julius Gudmundsson; Margret Jakobsdottir; Jon T Bergthorsson; Asgeir Sigurdsson; Thorarinn Blondal; J Alfred Witjes; Sita H Vermeulen; Christina A Hulsbergen-van de Kaa; Dorine W Swinkels; Martine Ploeg; Erik B Cornel; Henk Vergunst; Thorgeir E Thorgeirsson; Daniel Gudbjartsson; Sigurjon A Gudjonsson; Gudmar Thorleifsson; Kari T Kristinsson; Magali Mouy; Steinunn Snorradottir; Donatella Placidi; Marcello Campagna; Cecilia Arici; Kvetoslava Koppova; Eugene Gurzau; Peter Rudnai; Eliane Kellen; Silvia Polidoro; Simonetta Guarrera; Carlotta Sacerdote; Manuel Sanchez; Berta Saez; Gabriel Valdivia; Charlotta Ryk; Petra de Verdier; Annika Lindblom; Klaus Golka; D Timothy Bishop; Margaret A Knowles; Sigfus Nikulasson; Vigdis Petursdottir; Eirikur Jonsson; Gudmundur Geirsson; Baldvin Kristjansson; Jose I Mayordomo; Gunnar Steineck; Stefano Porru; Frank Buntinx; Maurice P Zeegers; Tony Fletcher; Rajiv Kumar; Giuseppe Matullo; Paolo Vineis; Anne E Kiltie; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Thorunn Rafnar; Kari Stefansson Journal: Nat Genet Date: 2008-09-14 Impact factor: 38.330
Authors: Xifeng Wu; Yuanqing Ye; Lambertus A Kiemeney; Patrick Sulem; Thorunn Rafnar; Giuseppe Matullo; Daniela Seminara; Teruhiko Yoshida; Norihisa Saeki; Angeline S Andrew; Colin P Dinney; Bogdan Czerniak; Zuo-feng Zhang; Anne E Kiltie; D Timothy Bishop; Paolo Vineis; Stefano Porru; Frank Buntinx; Eliane Kellen; Maurice P Zeegers; Rajiv Kumar; Peter Rudnai; Eugene Gurzau; Kvetoslava Koppova; Jose Ignacio Mayordomo; Manuel Sanchez; Berta Saez; Annika Lindblom; Petra de Verdier; Gunnar Steineck; Gordon B Mills; Alan Schned; Simonetta Guarrera; Silvia Polidoro; Shen-Chih Chang; Jie Lin; David W Chang; Katherine S Hale; Tadeusz Majewski; H Barton Grossman; Steinunn Thorlacius; Unnur Thorsteinsdottir; Katja K H Aben; J Alfred Witjes; Kari Stefansson; Christopher I Amos; Margaret R Karagas; Jian Gu Journal: Nat Genet Date: 2009-08-02 Impact factor: 38.330
Authors: Jonine D Figueroa; Yuanqing Ye; Afshan Siddiq; Montserrat Garcia-Closas; Nilanjan Chatterjee; Ludmila Prokunina-Olsson; Victoria K Cortessis; Charles Kooperberg; Olivier Cussenot; Simone Benhamou; Jennifer Prescott; Stefano Porru; Colin P Dinney; Núria Malats; Dalsu Baris; Mark Purdue; Eric J Jacobs; Demetrius Albanes; Zhaoming Wang; Xiang Deng; Charles C Chung; Wei Tang; H Bas Bueno-de-Mesquita; Dimitrios Trichopoulos; Börje Ljungberg; Françoise Clavel-Chapelon; Elisabete Weiderpass; Vittorio Krogh; Miren Dorronsoro; Ruth Travis; Anne Tjønneland; Paul Brenan; Jenny Chang-Claude; Elio Riboli; David Conti; Manuela Gago-Dominguez; Mariana C Stern; Malcolm C Pike; David Van Den Berg; Jian-Min Yuan; Chancellor Hohensee; Rebecca Rodabough; Geraldine Cancel-Tassin; Morgan Roupret; Eva Comperat; Constance Chen; Immaculata De Vivo; Edward Giovannucci; David J Hunter; Peter Kraft; Sara Lindstrom; Angela Carta; Sofia Pavanello; Cecilia Arici; Giuseppe Mastrangelo; Ashish M Kamat; Seth P Lerner; H Barton Grossman; Jie Lin; Jian Gu; Xia Pu; Amy Hutchinson; Laurie Burdette; William Wheeler; Manolis Kogevinas; Adonina Tardón; Consol Serra; Alfredo Carrato; Reina García-Closas; Josep Lloreta; Molly Schwenn; Margaret R Karagas; Alison Johnson; Alan Schned; Karla R Armenti; G M Hosain; Gerald Andriole; Robert Grubb; Amanda Black; W Ryan Diver; Susan M Gapstur; Stephanie J Weinstein; Jarmo Virtamo; Chris A Haiman; Maria T Landi; Neil Caporaso; Joseph F Fraumeni; Paolo Vineis; Xifeng Wu; Debra T Silverman; Stephen Chanock; Nathaniel Rothman Journal: Hum Mol Genet Date: 2013-10-24 Impact factor: 6.150
Authors: Nathaniel Rothman; Montserrat Garcia-Closas; Nilanjan Chatterjee; Nuria Malats; Xifeng Wu; Jonine D Figueroa; Francisco X Real; David Van Den Berg; Giuseppe Matullo; Dalsu Baris; Michael Thun; Lambertus A Kiemeney; Paolo Vineis; Immaculata De Vivo; Demetrius Albanes; Mark P Purdue; Thorunn Rafnar; Michelle A T Hildebrandt; Anne E Kiltie; Olivier Cussenot; Klaus Golka; Rajiv Kumar; Jack A Taylor; Jose I Mayordomo; Kevin B Jacobs; Manolis Kogevinas; Amy Hutchinson; Zhaoming Wang; Yi-Ping Fu; Ludmila Prokunina-Olsson; Laurie Burdett; Meredith Yeager; William Wheeler; Adonina Tardón; Consol Serra; Alfredo Carrato; Reina García-Closas; Josep Lloreta; Alison Johnson; Molly Schwenn; Margaret R Karagas; Alan Schned; Gerald Andriole; Robert Grubb; Amanda Black; Eric J Jacobs; W Ryan Diver; Susan M Gapstur; Stephanie J Weinstein; Jarmo Virtamo; Victoria K Cortessis; Manuela Gago-Dominguez; Malcolm C Pike; Mariana C Stern; Jian-Min Yuan; David J Hunter; Monica McGrath; Colin P Dinney; Bogdan Czerniak; Meng Chen; Hushan Yang; Sita H Vermeulen; Katja K Aben; J Alfred Witjes; Remco R Makkinje; Patrick Sulem; Soren Besenbacher; Kari Stefansson; Elio Riboli; Paul Brennan; Salvatore Panico; Carmen Navarro; Naomi E Allen; H Bas Bueno-de-Mesquita; Dimitrios Trichopoulos; Neil Caporaso; Maria Teresa Landi; Federico Canzian; Borje Ljungberg; Anne Tjonneland; Francoise Clavel-Chapelon; David T Bishop; Mark T W Teo; Margaret A Knowles; Simonetta Guarrera; Silvia Polidoro; Fulvio Ricceri; Carlotta Sacerdote; Alessandra Allione; Geraldine Cancel-Tassin; Silvia Selinski; Jan G Hengstler; Holger Dietrich; Tony Fletcher; Peter Rudnai; Eugen Gurzau; Kvetoslava Koppova; Sophia C E Bolick; Ashley Godfrey; Zongli Xu; José I Sanz-Velez; María D García-Prats; Manuel Sanchez; Gabriel Valdivia; Stefano Porru; Simone Benhamou; Robert N Hoover; Joseph F Fraumeni; Debra T Silverman; Stephen J Chanock Journal: Nat Genet Date: 2010-10-24 Impact factor: 38.330
Authors: Thorunn Rafnar; Patrick Sulem; Gudmar Thorleifsson; Sita H Vermeulen; Hannes Helgason; Jona Saemundsdottir; Sigurjon A Gudjonsson; Asgeir Sigurdsson; Simon N Stacey; Julius Gudmundsson; Hrefna Johannsdottir; Kristin Alexiusdottir; Vigdis Petursdottir; Sigfus Nikulasson; Gudmundur Geirsson; Thorvaldur Jonsson; Katja K H Aben; Anne J Grotenhuis; Gerald W Verhaegh; Aleksandra M Dudek; J Alfred Witjes; Antoine G van der Heijden; Alina Vrieling; Tessel E Galesloot; Ana De Juan; Angeles Panadero; Fernando Rivera; Carolyn Hurst; D Timothy Bishop; Sei C Sak; Ananya Choudhury; Mark T W Teo; Cecilia Arici; Angela Carta; Elena Toninelli; Petra de Verdier; Peter Rudnai; Eugene Gurzau; Kvetoslava Koppova; Kirstin A van der Keur; Irene Lurkin; Mieke Goossens; Eliane Kellen; Simonetta Guarrera; Alessia Russo; Rossana Critelli; Carlotta Sacerdote; Paolo Vineis; Clémentine Krucker; Maurice P Zeegers; Holger Gerullis; Daniel Ovsiannikov; Frank Volkert; Jan G Hengstler; Silvia Selinski; Olafur T Magnusson; Gisli Masson; Augustine Kong; Daniel Gudbjartsson; Annika Lindblom; Ellen Zwarthoff; Stefano Porru; Klaus Golka; Frank Buntinx; Giuseppe Matullo; Rajiv Kumar; José I Mayordomo; D Gunnar Steineck; Anne E Kiltie; Eirikur Jonsson; François Radvanyi; Margaret A Knowles; Unnur Thorsteinsdottir; Lambertus A Kiemeney; Kari Stefansson Journal: Hum Mol Genet Date: 2014-05-26 Impact factor: 6.150
Authors: J Ferlay; M Colombet; I Soerjomataram; C Mathers; D M Parkin; M Piñeros; A Znaor; F Bray Journal: Int J Cancer Date: 2018-12-06 Impact factor: 7.396