Qi Gao1,2,3, Congchao Lu4, Xiuying Tian1,2,3, Jun Zheng1,2,3, Fangrui Ding5,6,7. 1. Department of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, No. 156 Nan Kai San Ma Lu, Tianjin, 300000, China. 2. Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, 300000, China. 3. Department of Neonatology, Nankai University Maternity Hospital, Tianjin, 300000, China. 4. School of Public Health, Tianjin Medical University, Tianjin, 300000, China. 5. Department of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, No. 156 Nan Kai San Ma Lu, Tianjin, 300000, China. youngbear@126.com. 6. Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, 300000, China. youngbear@126.com. 7. Department of Neonatology, Nankai University Maternity Hospital, Tianjin, 300000, China. youngbear@126.com.
Abstract
BACKGROUND: Preterm birth has been identified as a risk factor for development of long-term chronic kidney disease. Podocyte loss has been reported to contribute to this process in preterm animal models. However, details about podocyte loss in preterm infants and related perinatal risk factors have not been well clarified. METHODS: Forty full-term infants and 106 preterm infants were enrolled. Urine samples were collected from full-term infants within 4-7 days of birth and preterm infants at 37-40 weeks of corrected age. Levels of urine podocin mRNA, urine protein (UP), and urine microalbumin (UMA) were measured, and the relationship between these markers was evaluated. Clinical information in these infants was collected, and potential correlates that may lead to increased podocyte loss during the perinatal period were identified using linear regression analysis. RESULTS: Urine podocyte loss indicated by the urine podocin mRNA to creatinine ratio (UpodCR) was higher in preterm infants than in full-term infants. UpodCR was correlated with the levels of UP and UMA. Multiple linear regression analysis also showed that lower gestational age (GA) at birth and small for gestational age (SGA) were high risk factors for urine podocyte loss. CONCLUSIONS: Increasing urine podocyte loss was identified in preterm infants. Moreover, perinatal factors were associated with podocyte loss and may be a potential direction for comprehensive research and intervention in this field. A higher resolution version of the Graphical abstract is available as Supplementary information.
BACKGROUND: Preterm birth has been identified as a risk factor for development of long-term chronic kidney disease. Podocyte loss has been reported to contribute to this process in preterm animal models. However, details about podocyte loss in preterm infants and related perinatal risk factors have not been well clarified. METHODS: Forty full-term infants and 106 preterm infants were enrolled. Urine samples were collected from full-term infants within 4-7 days of birth and preterm infants at 37-40 weeks of corrected age. Levels of urine podocin mRNA, urine protein (UP), and urine microalbumin (UMA) were measured, and the relationship between these markers was evaluated. Clinical information in these infants was collected, and potential correlates that may lead to increased podocyte loss during the perinatal period were identified using linear regression analysis. RESULTS: Urine podocyte loss indicated by the urine podocin mRNA to creatinine ratio (UpodCR) was higher in preterm infants than in full-term infants. UpodCR was correlated with the levels of UP and UMA. Multiple linear regression analysis also showed that lower gestational age (GA) at birth and small for gestational age (SGA) were high risk factors for urine podocyte loss. CONCLUSIONS: Increasing urine podocyte loss was identified in preterm infants. Moreover, perinatal factors were associated with podocyte loss and may be a potential direction for comprehensive research and intervention in this field. A higher resolution version of the Graphical abstract is available as Supplementary information.
Authors: Nienke M Scheltema; Elisabeth E Nibbelke; Juliëtte Pouw; Maarten O Blanken; Maroeska M Rovers; Christiana A Naaktgeboren; Natalie I Mazur; Joanne G Wildenbeest; Cornelis K van der Ent; Louis J Bont Journal: Lancet Respir Med Date: 2018-02-27 Impact factor: 30.700
Authors: Sarah L White; Vlado Perkovic; Alan Cass; Choon Lan Chang; Neil R Poulter; Tim Spector; Leigh Haysom; Jonathan C Craig; Isa Al Salmi; Steven J Chadban; Rachel R Huxley Journal: Am J Kidney Dis Date: 2009-04-01 Impact factor: 8.860