| Literature DB >> 3575379 |
M Brufani, C Castellano, M Marta, A Oliverio, P G Pagella, F Pavone, M Pomponi, P L Rugarli.
Abstract
A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation.Entities:
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Year: 1987 PMID： 3575379 DOI： 10.1016/0091-3057(87)90176-6
Source DB: PubMed Journal: Pharmacol Biochem Behav ISSN： 0091-3057 Impact factor: 3.533