| Literature DB >> 3575373 |
P J Elliott, G M Rosen, C B Nemeroff.
Abstract
Intraventricular and intraperitoneal administration of cocaine and its metabolite norcocaine were studied in adult male rats. Norcocaine (10-100 micrograms) had no behavioral activity following central infusion but proved to be toxic at high doses (50-100 mg/kg) when given peripherally. Cocaine at high doses (100 micrograms), produced possible hypoactivity after central injections but produced significant hyperactivity after peripheral administration (20 mg/kg).Entities:
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Year: 1987 PMID： 3575373 DOI： 10.1016/0091-3057(87)90168-7
Source DB: PubMed Journal: Pharmacol Biochem Behav ISSN： 0091-3057 Impact factor: 3.533