Haojun Yu1,2,3,4, Yushen Gu1,2,3,4, Wei Fan5, Yongju Gao6, Meiyun Wang6, Xiaohua Zhu7, Zhifang Wu8, Jianjun Liu9, Biao Li10, Hubing Wu11, Zhaoping Cheng12, Shuxia Wang13, Yiqiu Zhang1,2,3,4, Baixuan Xu14, Sijin Li15, Hongcheng Shi16,17,18,19. 1. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. 2. Shanghai Institute of Medical Imaging, Shanghai, 200032, China. 3. Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, China. 4. Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. 5. Department of Nuclear Medicine, Sun Yat-sen University Cancer Center, No. 651 Dongfendong Road, Guangzhou, 510060, China. 6. Department of Nuclear Medicine, Henan Provincial People's Hospital, Henan Key Laboratory of Noval Molecular Probes and Clinical Translation in Nuclear Medicine, No. 7 Weiwu Road, Zhengzhou, 450003, China. 7. Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China. 8. Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Collaborative Innovation Center for Molecular Imaging Precision Medicine, Taiyuan, 030001, China. 9. Department of Nuclear Medicine, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 PuJian Road, Shanghai, 200127, China. 10. Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, No. 197 Ruijin Er Road, Shanghai, 200025, China. 11. Nanfang PET Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, China. 12. Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University, No. 16766 Jingshi Road, Jinan, 250014, Shandong, China. 13. Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106 Zhongshan Er Road, Guangzhou, 510080, China. 14. Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, 100853, China. xbx301@163.com. 15. Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Collaborative Innovation Center for Molecular Imaging Precision Medicine, Taiyuan, 030001, China. lisjnm123@163.com. 16. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. shi.hongcheng@zs-hospital.sh.cn. 17. Shanghai Institute of Medical Imaging, Shanghai, 200032, China. shi.hongcheng@zs-hospital.sh.cn. 18. Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, China. shi.hongcheng@zs-hospital.sh.cn. 19. Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. shi.hongcheng@zs-hospital.sh.cn.
Abstract
BACKGROUND: [18F]FDG imaging on total-body PET/CT (TB PET/CT) scanners, with improved sensitivity, offers new potentials for cancer diagnosis, staging, and radiation treatment planning. This consensus provides the protocols for clinical practices with a goal of paving the way for future studies with the total-body scanners in oncological [18F]FDG TB PET/CT imaging. METHODS: The consensus was summarized based on the published guidelines and peer-reviewed articles of TB PET/CT in the literature, along with the opinions of the experts from major research institutions with a total of 40,000 cases performed on the TB PET/CT scanners. RESULTS: This consensus describes the protocols for routine and dynamic [18F]FDG TB PET/CT scanning focusing on the reduction of imaging acquisition time and FDG injected activity, which may serve as a reference for research and clinic oncological PET/CT studies. CONCLUSION: This expert consensus focuses on the reduction of acquisition time and FDG injected activity with a TB PET/CT scanner, which may improve the patient throughput or reduce the radiation exposure in daily clinical oncologic imaging. KEY POINTS: • [18F]FDG-imaging protocols for oncological total-body PET/CT with reduced acquisition time or with different FDG activity levels have been summarized from multicenter studies. • Total-body PET/CT provides better image quality and improved diagnostic insights. • Clinical workflow and patient management have been improved.
BACKGROUND: [18F]FDG imaging on total-body PET/CT (TB PET/CT) scanners, with improved sensitivity, offers new potentials for cancer diagnosis, staging, and radiation treatment planning. This consensus provides the protocols for clinical practices with a goal of paving the way for future studies with the total-body scanners in oncological [18F]FDG TB PET/CT imaging. METHODS: The consensus was summarized based on the published guidelines and peer-reviewed articles of TB PET/CT in the literature, along with the opinions of the experts from major research institutions with a total of 40,000 cases performed on the TB PET/CT scanners. RESULTS: This consensus describes the protocols for routine and dynamic [18F]FDG TB PET/CT scanning focusing on the reduction of imaging acquisition time and FDG injected activity, which may serve as a reference for research and clinic oncological PET/CT studies. CONCLUSION: This expert consensus focuses on the reduction of acquisition time and FDG injected activity with a TB PET/CT scanner, which may improve the patient throughput or reduce the radiation exposure in daily clinical oncologic imaging. KEY POINTS: • [18F]FDG-imaging protocols for oncological total-body PET/CT with reduced acquisition time or with different FDG activity levels have been summarized from multicenter studies. • Total-body PET/CT provides better image quality and improved diagnostic insights. • Clinical workflow and patient management have been improved.
Authors: Simon R Cherry; Ramsey D Badawi; Joel S Karp; William W Moses; Pat Price; Terry Jones Journal: Sci Transl Med Date: 2017-03-15 Impact factor: 17.956
Authors: T Beyer; D W Townsend; T Brun; P E Kinahan; M Charron; R Roddy; J Jerin; J Young; L Byars; R Nutt Journal: J Nucl Med Date: 2000-08 Impact factor: 10.057
Authors: Donna E Maziak; Gail E Darling; Richard I Inculet; Karen Y Gulenchyn; Albert A Driedger; Yee C Ung; John D Miller; Chu-Shu Gu; Kathryn J Cline; William K Evans; Mark N Levine Journal: Ann Intern Med Date: 2009-07-06 Impact factor: 25.391
Authors: Felisa Jiménez-Requena; Roberto C Delgado-Bolton; Cristina Fernández-Pérez; Sanjiv S Gambhir; Judy Schwimmer; José M Pérez-Vázquez; José L Carreras-Delgado Journal: Eur J Nucl Med Mol Imaging Date: 2009-09-02 Impact factor: 9.236