Literature DB >> 35747770

Personalised external aortic root support (PEARS) to stabilise an aortic root aneurysm.

John Pepper1, Cemil Izgi2, Tal J Golesworthy3, Johanna J M Takkenberg4, Tom Treasure5.   

Abstract

Patients with congenitally determined aortic root aneurysms are at risk of aortic valve regurgitation, aortic dissection, rupture and death. Personalised external aortic root support (PEARS) may provide an alternative to aortic root replacement. This was a multi-centre, prospective cohort of all consecutive patients who received ExoVasc mesh implants for a dilated aortic root between 2004 and 2017. Baseline and peri-operative characteristics, as well as early postoperative outcomes are described, and time-related survival and re-operation free survival are estimated using the Kaplan-Meier method. From 2004 through 2017, 117 consecutive patients have received ExoVasc mesh implants for aortic root aneurysm. The inclusion criteria were an aortic root/sinus of Valsalva and ascending aorta with asymptomatic dilatation of between 40 and 50 mm in diameter in patients aged 16 years or more. Patients with more than mild aortic regurgitation were excluded. There was one early death. The length of stay was within seven days in 75% of patients. In conclusion, the operation achieves the objectives of valve-sparing root replacement. PEARS may be seen as a low-risk conservative operation, which can be applied earlier on in the disease process, and which is complementary to more invasive procedures, such as valve-sparing root replacement or total root replacement.
Copyright © 2020 Medinews (Cardiology) Limited.

Entities:  

Keywords:  Marfan syndrome; aortic root aneurysm; personalised medicine; prophylactic surgery

Year:  2020        PMID: 35747770      PMCID: PMC9205243          DOI: 10.5837/bjc.2020.022

Source DB:  PubMed          Journal:  Br J Cardiol        ISSN: 0969-6113


  26 in total

1.  External aortic root support: NICE guidance.

Authors:  Tom Treasure; John Pepper; Tal Golesworthy; Raad Mohiaddin; Robert H Anderson
Journal:  Heart       Date:  2011-10-14       Impact factor: 5.994

2.  Aortic valve repair and aortic valve-sparing operations.

Authors:  Tirone E David
Journal:  J Thorac Cardiovasc Surg       Date:  2014-11-15       Impact factor: 5.209

3.  First beating-heart valve-sparing aortic root repair: a "corset" technique.

Authors:  Tomasz Plonek; Andrzej Dumanski; Marta Obremska; Wojciech Kustrzycki
Journal:  Ann Thorac Surg       Date:  2015-04       Impact factor: 4.330

4.  Reply to Jahangiri et al.

Authors:  Tom Treasure; John Pepper
Journal:  Eur J Cardiothorac Surg       Date:  2017-05-01       Impact factor: 4.191

5.  External support of the dilated aorta: back to the future?

Authors:  Duke Cameron
Journal:  Heart       Date:  2014-03-26       Impact factor: 5.994

6.  Implantation of an individually computer-designed and manufactured external support for the Marfan aortic root.

Authors:  John Pepper; Mario Petrou; Filip Rega; Ulrich Rosendahl; Tal Golesworthy; Tom Treasure
Journal:  Multimed Man Cardiothorac Surg       Date:  2013

7.  Life expectancy and causes of death in the Marfan syndrome.

Authors:  J L Murdoch; B A Walker; B L Halpern; J W Kuzma; V A McKusick
Journal:  N Engl J Med       Date:  1972-04-13       Impact factor: 91.245

8.  An Option for Concomitant Management of Moderate Marfan Root Aneurysm at the Time of Mitral Valve Repair: A Role for Personalized External Aortic Root Support.

Authors:  Umberto Benedetto; Xu Yu Jin; Elaine Hill; Tom Treasure; Mario Petrou
Journal:  Ann Thorac Surg       Date:  2016-12       Impact factor: 4.330

9.  Prognostic significance of the pattern of aortic root dilation in the Marfan syndrome.

Authors:  M J Roman; S E Rosen; R Kramer-Fox; R B Devereux
Journal:  J Am Coll Cardiol       Date:  1993-11-01       Impact factor: 24.094

10.  Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement.

Authors:  Tom Treasure; Johanna J M Takkenberg; Tal Golesworthy; Filip Rega; Mario Petrou; Ulrich Rosendahl; Raad Mohiaddin; Michael Rubens; Warren Thornton; Belinda Lees; John Pepper
Journal:  Heart       Date:  2014-01-06       Impact factor: 5.994

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