Lucas Alves1, Thaís Alcântara1, Adriano Hazin1, Leandro Lucato1, Jurandy Júnior Ferraz de Magalhães1, Joao Alves1, Jucille Meneses1. 1. Department of Neuropediatric (LA), Instituto de Medicina Integral Prof. Fernando Figueira (IMIP); Department of Neonatology (TA, JM), Instituto de Medicina Integral Prof. Fernando Figueira (IMIP); Department of Radiology (AH), Instituto de Medicina Integral Prof. Fernando Figueira (IMIP); Department of Radiology (LL), Hospital das Clínicas da Universidade de São Paulo; Department of Virology (JJFM), Pernambuco State Central Laboratory (LACEN/PE); and Department of Pediatrics (JA), Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil.
Abstract
Because the COVID-19 pandemic evolves, reports of neurologic manifestations and neuroimaging associated with SARS-CoV-2 have been reported in children and in neonates, although very few when compared with adults. Objectives: To describe a 3-day-old neonate presenting afebrile seizures with a persistent positive nasopharyngeal swab for SARS-CoV-2 and neuroimaging demonstrating extensive cerebral white matter injury. Methods: Consent was obtained to report this case. SARS-CoV-2 was tested using real-time reverse transcriptase-polymerase chain reaction amplification of virus acid from a nasopharyngeal swab. MRI of the brain was performed using axial T1, T2, fluid-attenuated inversion recovery, diffusion-weighted imaging, and T1 postcontrast sequences. Results: Brain MRI showed restricted diffusion in the periventricular white matter, subcortical white matter, and splenium of the corpus callosum. Discussion: Neurologic presentation of SARS-CoV-2 in newborns seems to be rare and is not fully known. SARS-CoV-2 infection should be considered in newborns with seizures and white matter abnormalities.
Because the COVID-19 pandemic evolves, reports of neurologic manifestations and neuroimaging associated with SARS-CoV-2 have been reported in children and in neonates, although very few when compared with adults. Objectives: To describe a 3-day-old neonate presenting afebrile seizures with a persistent positive nasopharyngeal swab for SARS-CoV-2 and neuroimaging demonstrating extensive cerebral white matter injury. Methods: Consent was obtained to report this case. SARS-CoV-2 was tested using real-time reverse transcriptase-polymerase chain reaction amplification of virus acid from a nasopharyngeal swab. MRI of the brain was performed using axial T1, T2, fluid-attenuated inversion recovery, diffusion-weighted imaging, and T1 postcontrast sequences. Results: Brain MRI showed restricted diffusion in the periventricular white matter, subcortical white matter, and splenium of the corpus callosum. Discussion: Neurologic presentation of SARS-CoV-2 in newborns seems to be rare and is not fully known. SARS-CoV-2 infection should be considered in newborns with seizures and white matter abnormalities.
Authors: Rachelle Dugue; Karla C Cay-Martínez; Kiran T Thakur; Joel A Garcia; Lokendra V Chauhan; Simon H Williams; Thomas Briese; Komal Jain; Marc Foca; Danielle K McBrian; Jennifer M Bain; W Ian Lipkin; Nischay Mishra Journal: Neurology Date: 2020-04-23 Impact factor: 9.910
Authors: Adélia Maria de Miranda Henriques-Souza; Ana Cláudia Marques Gouveia de Melo; Bianca de Aguiar Coelho Silva Madeiro; Leonardo Furtado Freitas; Pedro Augusto Sampaio Rocha-Filho; Fabrício Guimarães Gonçalves Journal: Neuroradiology Date: 2020-10-01 Impact factor: 2.804