Literature DB >> 35747418

Primary prevention aspirin among the elderly: challenges in translating trial evidence to the clinic.

J William McEvoy1, Michael Keane2, Justin Ng3.   

Abstract

The ASPirin in Reducing Events in the Elderly trial (ASPREE) contributed important knowledge about primary cardiovascular disease (CVD) prevention among healthy older adults. The finding that daily low-dose aspirin (LDA) does not statistically prevent disability or CVD among adults aged over 70 years when compared with placebo, but does significantly increase risk of haemorrhage, immediately influenced clinical practice guidelines. In this article, we discuss nuances of the trial that may impact the extrapolation of the ASPREE trial results to the everyday individual clinical care of older adults.
Copyright © 2020 Medinews (Cardiology) Limited.

Entities:  

Keywords:  aspirin; cardiovascular disease; elderly patients; primary prevention

Year:  2020        PMID： 35747418      PMCID： PMC8793932          DOI： 10.5837/bjc.2020.007

Source DB:  PubMed          Journal:  Br J Cardiol        ISSN： 0969-6113


  7 in total

Review 1.  The rise and fall of aspirin in the primary prevention of cardiovascular disease.

Authors:  Inbar Raber; Cian P McCarthy; Muthiah Vaduganathan; Deepak L Bhatt; David A Wood; John G F Cleland; Roger S Blumenthal; John W McEvoy
Journal:  Lancet       Date:  2019-05-25       Impact factor: 79.321

2.  ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.

Authors:  Deepak L Bhatt; James Scheiman; Neena S Abraham; Elliott M Antman; Francis K L Chan; Curt D Furberg; David A Johnson; Kenneth W Mahaffey; Eamonn M Quigley; Robert A Harrington; Eric R Bates; Charles R Bridges; Mark J Eisenberg; Victor A Ferrari; Mark A Hlatky; Sanjay Kaul; Jonathan R Lindner; David J Moliterno; Debabrata Mukherjee; Richard S Schofield; Robert S Rosenson; James H Stein; Howard H Weitz; Deborah J Wesley
Journal:  J Am Coll Cardiol       Date:  2008-10-28       Impact factor: 24.094

3.  Levels of Evidence Supporting American College of Cardiology/American Heart Association and European Society of Cardiology Guidelines, 2008-2018.

Authors:  Alexander C Fanaroff; Robert M Califf; Stephan Windecker; Sidney C Smith; Renato D Lopes
Journal:  JAMA       Date:  2019-03-19       Impact factor: 56.272

4.  Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients.

Authors:  Hilary Hamilton; Paul Gallagher; Cristin Ryan; Stephen Byrne; Denis O'Mahony
Journal:  Arch Intern Med       Date:  2011-06-13

5.  Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin.

Authors:  Paul Moayyedi; John W Eikelboom; Jackie Bosch; Stuart J Connolly; Leanne Dyal; Olga Shestakovska; Darryl Leong; Sonia S Anand; Stefan Störk; Kelley R H Branch; Deepak L Bhatt; Peter B Verhamme; Martin O'Donnell; Aldo P Maggioni; Eva M Lonn; Leopoldo S Piegas; Georg Ertl; Matyas Keltai; Nancy Cook Bruns; Eva Muehlhofer; Gilles R Dagenais; Jae-Hyung Kim; Masatsugu Hori; P Gabriel Steg; Robert G Hart; Rafael Diaz; Marco Alings; Petr Widimsky; Alvaro Avezum; Jeffrey Probstfield; Jun Zhu; Yan Liang; Patricio Lopez-Jaramillo; Ajay K Kakkar; Alexander N Parkhomenko; Lars Ryden; Nana Pogosova; Antonio L Dans; Fernando Lanas; Patrick J Commerford; Christian Torp-Pedersen; Tomek J Guzik; Dragos Vinereanu; Andrew M Tonkin; Basil S Lewis; Camilo Felix; Khalid Yusoff; Kaj P Metsarinne; Keith A A Fox; Salim Yusuf
Journal:  Gastroenterology       Date:  2019-05-29       Impact factor: 22.682

6.  Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.

Authors:  John J McNeil; Rory Wolfe; Robyn L Woods; Andrew M Tonkin; Geoffrey A Donnan; Mark R Nelson; Christopher M Reid; Jessica E Lockery; Brenda Kirpach; Elsdon Storey; Raj C Shah; Jeff D Williamson; Karen L Margolis; Michael E Ernst; Walter P Abhayaratna; Nigel Stocks; Sharyn M Fitzgerald; Suzanne G Orchard; Ruth E Trevaks; Lawrence J Beilin; Colin I Johnston; Joanne Ryan; Barbara Radziszewska; Michael Jelinek; Mobin Malik; Charles B Eaton; Donna Brauer; Geoff Cloud; Erica M Wood; Suzanne E Mahady; Suzanne Satterfield; Richard Grimm; Anne M Murray
Journal:  N Engl J Med       Date:  2018-09-16       Impact factor: 91.245

Review 7.  2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Authors:  Donna K Arnett; Roger S Blumenthal; Michelle A Albert; Andrew B Buroker; Zachary D Goldberger; Ellen J Hahn; Cheryl Dennison Himmelfarb; Amit Khera; Donald Lloyd-Jones; J William McEvoy; Erin D Michos; Michael D Miedema; Daniel Muñoz; Sidney C Smith; Salim S Virani; Kim A Williams; Joseph Yeboah; Boback Ziaeian
Journal:  Circulation       Date:  2019-03-17       Impact factor: 29.690
  7 in total

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