Literature DB >> 35747067

Statin prescription and CV risk assessment in adult psychiatric outpatients with intellectual disability.

Jamie Sin Ying Ho1, George Collins2, Vikram Rohra3, Laura Korb4, Bhathika Perera4.   

Abstract

We performed a single-centre study to assess the risk of cardiovascular disease (CVD) in psychiatry outpatients with intellectual disability (ID) using the QRISK-3 score. There were 143 patients known to the ID psychiatry clinic enrolled. Of these, 28 (19.6%) had elevated CVD risk - defined as 10-year risk of heart attack or stroke of ≥10%. Of these, 57.1% were not prescribed statin therapy, which - after lifestyle measures - is recommended by National Institute for Health and Care Excellence (NICE) guidelines. The mean QRISK-3 score was 6.31% (95% confidence interval [CI] 4.84 to 7.78), with a relative risk of 3.50 (95%CI 2.34 to 4.67) compared with matched controls. The high CVD risk identified in this study supports routine CVD risk assessment and management in adult outpatients with ID. Appropriate lifestyle measures and statin therapy could help reduce the excess CVD-related morbidity and mortality in ID patients.
Copyright © 2021 Medinews (Cardiology) Limited.

Entities:  

Keywords:  cardiovascular diseases; intellectual disability; primary prevention; risk stratification

Year:  2021        PMID: 35747067      PMCID: PMC9063702          DOI: 10.5837/bjc.2021.049

Source DB:  PubMed          Journal:  Br J Cardiol        ISSN: 0969-6113


  10 in total

1.  Mental ill-health in adults with intellectual disabilities: prevalence and associated factors.

Authors:  Sally-Ann Cooper; Elita Smiley; Jillian Morrison; Andrew Williamson; Linda Allan
Journal:  Br J Psychiatry       Date:  2007-01       Impact factor: 9.319

Review 2.  Cardiovascular disease prevalence and risk factors of persons with mental retardation.

Authors:  Christopher C Draheim
Journal:  Ment Retard Dev Disabil Res Rev       Date:  2006

3.  The Confidential Inquiry into premature deaths of people with intellectual disabilities in the UK: a population-based study.

Authors:  Pauline Heslop; Peter S Blair; Peter Fleming; Matthew Hoghton; Anna Marriott; Lesley Russ
Journal:  Lancet       Date:  2013-12-11       Impact factor: 79.321

4.  Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls.

Authors:  Christoph U Correll; Marco Solmi; Nicola Veronese; Beatrice Bortolato; Stella Rosson; Paolo Santonastaso; Nita Thapa-Chhetri; Michele Fornaro; Davide Gallicchio; Enrico Collantoni; Giorgio Pigato; Angela Favaro; Francesco Monaco; Cristiano Kohler; Davy Vancampfort; Philip B Ward; Fiona Gaughran; André F Carvalho; Brendon Stubbs
Journal:  World Psychiatry       Date:  2017-06       Impact factor: 49.548

5.  Cardiovascular risk factors (diabetes, hypertension, hypercholesterolemia and metabolic syndrome) in older people with intellectual disability: results of the HA-ID study.

Authors:  C F de Winter; L P Bastiaanse; T I M Hilgenkamp; H M Evenhuis; M A Echteld
Journal:  Res Dev Disabil       Date:  2012-06-13

6.  2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Authors:  Donna K Arnett; Roger S Blumenthal; Michelle A Albert; Andrew B Buroker; Zachary D Goldberger; Ellen J Hahn; Cheryl Dennison Himmelfarb; Amit Khera; Donald Lloyd-Jones; J William McEvoy; Erin D Michos; Michael D Miedema; Daniel Muñoz; Sidney C Smith; Salim S Virani; Kim A Williams; Joseph Yeboah; Boback Ziaeian
Journal:  J Am Coll Cardiol       Date:  2019-03-17       Impact factor: 24.094

7.  Health characteristics and consultation patterns of people with intellectual disability: a cross-sectional database study in English general practice.

Authors:  Iain M Carey; Sunil M Shah; Fay J Hosking; Stephen DeWilde; Tess Harris; Carole Beighton; Derek G Cook
Journal:  Br J Gen Pract       Date:  2016-02-23       Impact factor: 5.386

8.  Quality of prescribing of antipsychotic medication for people with intellectual disability under the care of UK mental health services: a cross-sectional audit of clinical practice.

Authors:  Carol Paton; Sumera Bhatti; Kiran Purandare; Ashok Roy; Tre Barnes
Journal:  BMJ Open       Date:  2016-12-05       Impact factor: 2.692

9.  Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study.

Authors:  Julia Hippisley-Cox; Carol Coupland; Peter Brindle
Journal:  BMJ       Date:  2017-05-23

Review 10.  The intriguing relationship between coronary heart disease and mental disorders.

Authors:  Marc De Hert; Johan Detraux; Davy Vancampfort
Journal:  Dialogues Clin Neurosci       Date:  2018-03       Impact factor: 5.986

  10 in total

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