Literature DB >> 3574674

Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles.

C R Emory, T A Ala, W H Frey.   

Abstract

Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles both in isolated neurofibrillary tangle-bearing nerve cells and in partially purified preparations of tangle fibers. Antibody staining was preabsorbed by preincubation of antibody with neuronal ganglioside preparations. These results suggest that Alzheimer's neurofibrillary tangles have a ganglioside associated with them.

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Year:  1987        PMID： 3574674     DOI： 10.1212/wnl.37.5.768

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  6 in total

1.  Expression in cultured human neuroblastoma cells of epitopes associated with affected neurons in Alzheimer's disease.

Authors:  L W Ko; K F Sheu; O Young; H Thaler; J P Blass
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

2.  Pick's disease immunohistochemistry: new alterations and Alzheimer's disease comparisons.

Authors:  O Yasuhara; A Matsuo; I Tooyama; H Kimura; E G McGeer; P L McGeer
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

3.  Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5.

Authors:  H Takahashi; K Hirokawa; S Ando; K Obata
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

4.  C-series polysialogangliosides are expressed on stellate neurons of adult human cerebellum.

Authors:  M Heffer-Lauc; M Cacić; D Serman
Journal:  Glycoconj J       Date:  1998-04       Impact factor: 2.916

5.  Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease.

Authors:  E J Mufson; J H Kordower
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205

6.  Abnormal Tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type.

Authors:  S Flament; A Delacourte; M Verny; J J Hauw; F Javoy-Agid
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088
  6 in total

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