| Literature DB >> 3574291 |
Abstract
The computer-automated structure evaluation (CASE) program has been applied to the evaluation of antileukemic (L1210) and toxic activities of an extensive series of 9-anilinoacridines. Major molecular fragments relevant to the respective biological endpoints were automatically generated and incorporated within equations used to estimate the degree of activity. Correlations of these activating/inactivating fragments with the biological activities are discussed.Entities:
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Year: 1987 PMID： 3574291
Source DB: PubMed Journal: Mol Pharmacol ISSN： 0026-895X Impact factor: 4.436