| Literature DB >> 35742633 |
Chee Keong Wee1,2, Xujuan Zhou1, Ruiliang Sun2, Raj Gururajan1, Xiaohui Tao3, Yuefeng Li4, Nathan Wee5.
Abstract
Triaging of medical referrals can be completed using various machine learning techniques, but trained models with historical datasets may not be relevant as the clinical criteria for triaging are regularly updated and changed. This paper proposes the use of machine learning techniques coupled with the clinical prioritisation criteria (CPC) of Queensland (QLD), Australia, to deliver better triaging for referrals in accordance with the CPC's updates. The unique feature of the proposed model is its non-reliance on the past datasets for model training. Medical Natural Language Processing (NLP) was applied in the proposed approach to process the medical referrals, which are unstructured free text. The proposed multiclass classification approach achieved a Micro F1 score = 0.98. The proposed approach can help in the processing of two million referrals that the QLD health service receives annually; therefore, they can deliver better and more efficient health services.Entities:
Keywords: healthcare AI; machine learning; medical NLP; triaging
Mesh:
Year: 2022 PMID: 35742633 PMCID: PMC9224242 DOI: 10.3390/ijerph19127384
Source DB: PubMed Journal: Int J Environ Res Public Health ISSN: 1660-4601 Impact factor: 4.614
Figure 1The architecture of a proposed CPC-based referral triaging system.
A section of CPC on ophthalmology speciality and conditions [28].
| Group | Condition | Criteria | Category |
|---|---|---|---|
| Adult | Age-related macular degeneration | New onset of reduced central vision and/or distortion due to wet AMD. Referral to continue treatment of wet AMD | 1 |
| Adult | Age-related macular degeneration | Recent significant progression of dry AMD | 2 |
| Adult | Allergic eye disease | Severe allergic eye disease with corneal involvement | 1 |
| Adult | Allergic eye disease | Severe allergic eye disease without corneal involvement (thickened eyelids, stringy mucoid discharge, severe itch) | 2 |
| Adult | Allergic eye disease | Mild allergic eye disease without corneal involvement that is non-responsive to topical antihistamines or mast cell stabilisers | 3 |
| Paediatric | Anisocoria (unequal pupil size) | Non-acute onset anisocoria | 1 |
| Adult | Cataracts | Documented cataract with documented significant impact on activities of daily living (ADL) and BCVA worse than 6/36 in each eye | 1 |
| Adult | Cataracts | Documented cataract with significant impact on ADL and: BCVA worse than 6/36 in one eye or BCVA worse than 6/12 in each eye | 2 |
| Adult | Cataracts | Documented cataract with significant impact on ADL and BCVA worse than 6/12 in either eye | 3 |
| Paediatric | Chalazion/meibomian cyst | Periorbital cellulitis associated with infected chalazion | 1 |
| Paediatric | Chalazion/meibomian cyst | Chalazion-associated pyogenic granuloma in a child | 2 |
| Paediatric | Chalazion/meibomian cyst | Failed maximal medical management of inflammatory eyelid mass (chalazion) | 3 |
CPC for ophthalmology’s under diabetic retinopathy condition and minimum referral criteria [28].
| Category | Referral Criteria |
|---|---|
| Category 1 (appointment within 30 calendar days) | Diagnosis of diabetes and any of the following: |
|
Proliferative diabetic retinopathy (PDR) Vitreous haemorrhage Severe NPDR Assessment of diabetic retinopathy in pregnancy Centre involving diabetic macular oedema (Definition: thickening within 500 microns of the foveal centre associated with microaneurysms, haemorrhages or hard exudates) | |
| Category 2 (appointment within 90 calendar days) | Diagnosis of diabetes and any of the following: |
|
Moderate NPDR Non-centre involving diabetic macular oedema (Definition: thickening within 2-disc diameters (but not within 500 microns) of the foveal centre associated with microaneurysms, haemorrhages or hard exudates). | |
| Category 3 (appointment within 365 calendar days) | No category 3 criteria. NB: Routine referral for screening without evidence of diabetic retinopathy, or for mild NPDR, will not be accepted. |
Figure 2The illustration of cosine similarity.
Test referral input and output of CPC’s condition matching.
| Input | Output |
|---|---|
| “patient A is a 70 years old male, born in Singapore. He suffered from eye haemorrhage with macular oedema. we found that his retina has some exudates and several microaneurysms. I am referring him to you.” |
referral = ‘microaneurysms’, ‘exudates’, ‘retina’, ‘eye haemorrhage’, ‘macular oedema’ Confidence scoring: 11.952286093343936 Ophthalmology—ADULT—Diabetic retinopathy—1 Confidence scoring: 14.142135623730951 Ophthalmology—ADULT—Diabetic retinopathy—2 |
Matching of referral’s medical vectors to several CPC condition vectors.
| Examples | Vectors and Similarity Scores |
|---|---|
| Example 1 |
‘diabetic retinopathy’, ‘hard exudates’, ‘diabetic macular oedema’, ‘PDR’, ‘NPDR’, ‘diabetes’, ‘macular oedema’, ‘Vitreous haemorrhage’, ‘microanaurysms’, ‘thickening’, ‘exudates’, ‘retina’, ‘foveal centre’, ‘proliferative diabetic retinopathy’, ‘eye hemorrhage’, ‘haemorrhages’, ‘500’, ‘pregnancy’
similarity1: 11.952286093343936 |
| Example 2 |
‘microanaurysms’, ‘exudates’, ‘retina’, ‘corneal involvement’, ‘eye hemorrhage’, ‘allergic eye disease’, ‘macular oedema’
similarity2: 0.0 |
| Example 3 |
‘microanaurysms’, ‘exudates’, ‘retina’, ‘6/36’, ‘eye hemorrhage’, ‘6/12’, ‘cataract’, ‘eye’, ‘macular oedema’
similarity3: 0.0 |
Results of triaged referrals vs. actual dataset.
| Predicted Cat 1 | Predicted Cat 2 | Predicted Cat 3 | |
|---|---|---|---|
| Actual Cat 1 | 978 | 13 | 2 |
| Actual Cat 2 | 20 | 986 | 13 |
| Actual Cat 3 | 2 | 1 | 987 |
Conversion from multiclass to binary classification confusion matrix.
| TP | TN | FP | FN | |
|---|---|---|---|---|
| Category 1 | 978 | 1987 | 15 | 22 |
| Category 2 | 986 | 1969 | 33 | 14 |
| Category 3 | 987 | 1997 | 3 | 15 |
Measurement for each category.
| Class | Precision | Recall | |
|---|---|---|---|
| Category 1 | 0.98 | 0.3298 | 0.493517 |
| Category 2 | 0.96 | 0.3336 | 0.495139 |
| Category 3 | 0.99 | 0.3307 | 0.495787 |