Recent Developments on Ionic Liquids and Deep Eutectic Solvents for Drug Delivery Applications.

The field of Ionic liquids (ILs) and deep eutectic solvents (DESs) is continuously expanding due to their exceptional unique properties and highly tunable nature, which finds applications in broad areas of modern science. Considering numerous possible IL and DES combinations prepared with active pharmaceutical ingredients (APIs), they find applications in pharmaceutical sciences. They can also serve as potential components of drug formulations and hence they have drawn the attention of formulation scientists. Herein, the concept of pharmaceutical ILs and DESs are discussed briefly. The possible applications of these solvent systems for slow drug delivery including nanoscale drug delivery are discussed citing various examples from the published literature. Although the ILs and DESs are found to be suitable for various drug delivery applications but still none of the slow drug delivery vehicles based on these solvents is in practical use. The data relating to long-term toxicity upon administration in the human body followed by various safety evaluations, clinical trials, etc. are pending for such new drug delivery systems. However, proof of concept studies done on the retention of biological activities in the ionic form is quite encouraging and such studies indicate the possibility of application of such new systems in the development of biomedical research and related industries in near future.