Literature DB >> 35734360

A Rare Case of Gestational Choriocarcinoma with Lung and Vaginal Metastases with Obstructive Jaundice.

Shivani Gupta1, Manisha Jhirwal1, Charu Sharma1, Shashank Shekhar1.   

Abstract

Choriocarcinoma is a rare highly malignant neoplasm which may present with early metastases as it has a propensity of rapid haematogenous spread. However the neoplasm is chemosensitive and has a good prognosis even in advanced stages. We are presenting a case of a 26 years old female with early pregnancy presented with lung and vaginal metastases with obstructive jaundice. [International Federation of Gynaecology and Obstetrics (FIGO) stage III; World Health Organization score, 14]. Serum beta-hCG was 3,61,131 mIU/ml. Radiological evaluation suggested marked lung metastases with vaginal metastases. Patient was started on single agent chemotherapy doxorubicin in view of deranged liver function test. Patient was given 5 cycles of doxorubicin with liver function test and beta hcg monitoring. After liver function test normalized, patient was shifted to EMACO regimen for 6 cycles of treatment dose and 2 cycles of maintenance dose. © Federation of Obstetric & Gynecological Societies of India 2021.

Entities:  

Keywords:  Beta hCG; Chemotherapy; Doxorubicin; EMACO; Molar pregnancy

Year:  2021        PMID: 35734360      PMCID: PMC9206957          DOI: 10.1007/s13224-021-01490-1

Source DB:  PubMed          Journal:  J Obstet Gynaecol India        ISSN: 0975-6434


  4 in total

Review 1.  Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.

Authors:  John R Lurain
Journal:  Am J Obstet Gynecol       Date:  2010-08-21       Impact factor: 8.661

2.  Treatment of extremely high risk and resistant gestational trophoblastic neoplasia patients in King Chulalongkorn Memorial Hospital.

Authors:  Shina Oranratanaphan; Ruangsak Lertkhachonsuk
Journal:  Asian Pac J Cancer Prev       Date:  2014

3.  Current chemotherapeutic management of patients with gestational trophoblastic neoplasia.

Authors:  Taymaa May; Donald P Goldstein; Ross S Berkowitz
Journal:  Chemother Res Pract       Date:  2011-05-11

Review 4.  First-line chemotherapy in low-risk gestational trophoblastic neoplasia.

Authors:  Theresa A Lawrie; Mo'iad Alazzam; John Tidy; Barry W Hancock; Raymond Osborne
Journal:  Cochrane Database Syst Rev       Date:  2016-06-09
  4 in total

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