Jean-Luc Perrot1,2, François Maccari2,3, Philippe Guillem2,4,5,6, Anne-Claire Fougerousse2,7, Aude Nassif2,8, Nathalie Beneton2,9, Elisa Cinotti2,10, Céline Girard2,11, Raphaelle Binois2,12, Ziad Reguiaï2,13. 1. Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France. 2. ResoVerneuil, Ville, France. 3. Private Office, La Varenne St Hilaire, France. 4. Service de chirurgie adulte, clinique du Val-d'Ouest, Ecully, 69130, France. 5. European Hidradenitis Suppurativa Foundation, Dessau, Germany. 6. Groupe de Recherche En proctologie de la Société Nationale Francophone de Colo-Proctologie, Paris, France. 7. Military Teaching Hospital Bégin, Saint Mandé, France. 8. Centre Médical de l'Institut Pasteur, Paris, 75015, France. 9. Dermatology Department, Centre Hospitalier du Mans, Le Mans, France. 10. Department of Medical, Dermatology Unit, Surgical and Neuro.Sciences, University of Siena, Siena, Italy. 11. Dermatology Department, Centre Hospitalier Universitaire de Montpellier, Montpellier, France. 12. Dermatology Department, Centre Hospitalier Régional d'Orléans, Orléans Cedex, 45067, France. 13. Service de dermatologie, polyclinique Courlancy, Reims, 51100, France.
Abstract
Purpose: Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by recurrent or chronic painful and suppurating lesions in the apocrine gland-bearing regions. The lack of knowledge about HS and its extremely heterogeneous clinical presentation, in terms of both lesion appearance and sites of involvement, frequently delay its diagnosis for several years. Objectives: in this study, using the latent class analysis, it was demonstrated that severity of HS could be evaluated not only with clinical or surgical characteristics but also with gender specificities. Patients and Methods: Clinical and sociodemographic data of HS patients were retrospectively analysed with the latent class method in order to create a classification tool of disease severity. Results: From the study of 1428 HS patients (544 men and 884 women), two classification models, depending on gender, were developed. Each classification model was composed of three distinct latent classes clearly identified and defined from mild-to-severe cases of HS. These classification models of HS severity were not distorted by patient ages and were coherent with Hurley stages but were more clinically precise. Conclusion: In this study, a convenient classification tool, useful for facilitating decision support in routine practice, has been developed. This tool could be used to define clinical subgroups within a study population.
Purpose: Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by recurrent or chronic painful and suppurating lesions in the apocrine gland-bearing regions. The lack of knowledge about HS and its extremely heterogeneous clinical presentation, in terms of both lesion appearance and sites of involvement, frequently delay its diagnosis for several years. Objectives: in this study, using the latent class analysis, it was demonstrated that severity of HS could be evaluated not only with clinical or surgical characteristics but also with gender specificities. Patients and Methods: Clinical and sociodemographic data of HS patients were retrospectively analysed with the latent class method in order to create a classification tool of disease severity. Results: From the study of 1428 HS patients (544 men and 884 women), two classification models, depending on gender, were developed. Each classification model was composed of three distinct latent classes clearly identified and defined from mild-to-severe cases of HS. These classification models of HS severity were not distorted by patient ages and were coherent with Hurley stages but were more clinically precise. Conclusion: In this study, a convenient classification tool, useful for facilitating decision support in routine practice, has been developed. This tool could be used to define clinical subgroups within a study population.