Symeon H Panagiotakis1, Panagiotis Simos2, Maria Basta2, Ioannis Zaganas3, Garyfalia S Perysinaki4, Ioannis Akoumianakis1, Chariklia Tziraki5, Christos Lionis6, Alexandros Vgontzas2, Dimitrios Boumpas7. 1. Internal Medicine Department, Heraklion University Hospital, Heraklion, Crete, Greece. 2. Psychiatry Department, Medical School, University of Crete, Heraklion, Crete, Greece. 3. Neurology Department, Medical School, University of Crete, Heraklion, Crete, Greece. 4. Nephrology Department, Rethymnon General Hospital, Rethymnon, Crete, Greece. 5. MELABEV, Research Institute, Community Elders Clubs and Institute for Gerontological Data Bases, Hebrew University, Jerusalem, Israel. 6. Clinic of Social and Family Medicine, Medical School, University of Crete, Heraklion, Crete, Greece. 7. Internal Medicine Department, Medical School, University of Athens, Athens, Greece.
Abstract
Objective:Comprehensive characterization of potential frailty determinants, including sociodemographic, clinical, dietary, psychological, cognitive and systemic inflammation parameters. Methods: A rural cohort of 186 subjects aged 60-89 years recruited from a community-based study in Crete, Greece (the Cretan Aging Cohort). Frailty was assessed with the Simple "Frail" Questionnaire Screening Tool. Results: Univariate analyses revealed significant (a) positive associations (p<0.01) between frailty and age, widowhood, Geriatric Depression Scale (GDS) score, waist circumference, polypharmacy, IL-6 and (b) negative associations between frailty and frequency of contact with friends, Mini Mental State Examination (MMSE), and adherence to the Mediterranean diet. Multivariate analyses revealed a significant independent contribution of the following variables to frailty: age (B=0.035, p<0.001), GDS score (B=0.041, p=0.034), polypharmacy (B=0.568, p<0.001), waist circumference (B=0.015, p=0,006), plasma IL-6 levels (B=0.189, p=0.004), and adherence to the Mediterranean diet (B=-0.036, p=0.015). Conclusion: Older age, depression symptoms, polypharmacy, waist circumference, poor adherence to Mediterranean diet and IL-6 plasma levels are associated with increased frailty.
Objective:Comprehensive characterization of potential frailty determinants, including sociodemographic, clinical, dietary, psychological, cognitive and systemic inflammation parameters. Methods: A rural cohort of 186 subjects aged 60-89 years recruited from a community-based study in Crete, Greece (the Cretan Aging Cohort). Frailty was assessed with the Simple "Frail" Questionnaire Screening Tool. Results: Univariate analyses revealed significant (a) positive associations (p<0.01) between frailty and age, widowhood, Geriatric Depression Scale (GDS) score, waist circumference, polypharmacy, IL-6 and (b) negative associations between frailty and frequency of contact with friends, Mini Mental State Examination (MMSE), and adherence to the Mediterranean diet. Multivariate analyses revealed a significant independent contribution of the following variables to frailty: age (B=0.035, p<0.001), GDS score (B=0.041, p=0.034), polypharmacy (B=0.568, p<0.001), waist circumference (B=0.015, p=0,006), plasma IL-6 levels (B=0.189, p=0.004), and adherence to the Mediterranean diet (B=-0.036, p=0.015). Conclusion: Older age, depression symptoms, polypharmacy, waist circumference, poor adherence to Mediterranean diet and IL-6 plasma levels are associated with increased frailty.
Authors: Tiago da S Alexandre; Ligiana P Corona; Tábatta R P Brito; Jair L F Santos; Yeda A O Duarte; Maria L Lebrão Journal: J Aging Health Date: 2016-10-04
Authors: Pinar Soysal; Nicola Veronese; Trevor Thompson; Kai G Kahl; Brisa S Fernandes; A Matthew Prina; Marco Solmi; Patricia Schofield; Ai Koyanagi; Ping-Tao Tseng; Pao-Yao Lin; Che-Sheng Chu; Theodore D Cosco; Matteo Cesari; Andre F Carvalho; Brendon Stubbs Journal: Ageing Res Rev Date: 2017-03-31 Impact factor: 10.895
Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: K Katsouyanni; E B Rimm; C Gnardellis; D Trichopoulos; E Polychronopoulos; A Trichopoulou Journal: Int J Epidemiol Date: 1997 Impact factor: 7.196