Martina Giacalone1, Luca Pierantoni2, Valeria Selvi3,4, Antonino Morabito5, Michelangelo Baldazzi6, Mario Lima7, Marcello Lanari2, Stefano Masi8, Filippo Incerti5, Francesca Fierro4, Massimo Basile4, Roberto Lo Piccolo5, Vincenzo Davide Catania7, Irene Bettini2, Niccolò Parri9. 1. Department of Emergency Medicine and Trauma Center, Meyer University Children's Hospital, Florence, Italy. martina.giacalone@meyer.it. 2. Pediatric Emergency Unit, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Bologna, Italy. 3. Department of Experimental and Clinical Biomedical Sciences Radiodiagnostic Unit 2, University of Florence, Careggi University Hospital, Florence, Italy. 4. Radiology Department, Meyer University Children's Hospital, Florence, Italy. 5. Department of Emergency, Critical Area and Pediatric Surgery, Meyer University Children's Hospital, University of Florence, Florence, Italy. 6. Pediatric Radiology, S. Orsola University Hospital, Bologna, Italy. 7. Pediatric Surgery, S. Orsola University Hospital, Bologna, Italy. 8. Department of Emergency Medicine, Meyer University Children's Hospital, Florence, Italy. 9. Department of Emergency Medicine and Trauma Center, Meyer University Children's Hospital, Florence, Italy.
Abstract
Ileocolic intussusception is a common cause of bowel obstruction. When spontaneous reduction does not occur, non-operative management through enema reduction is necessary. Despite the evidence indicating that sedatives favor success in the reduction, their use is still not a common practice. To determine if midazolam (MDZ) before enema improves the rate of procedure success, we retrospectively reviewed charts of patients admitted to two Italian pediatric emergency departments. Outcome measures were the success rate of the enema, recurrence, and need for surgery. Patients were grouped according to the use of MDZ or not, before hydrostatic reduction attempt. We included 69 and 37 patients in the MDZ and non-MDZ groups, respectively. The two groups did not differ in demographics, clinical characteristics, and ultrasound findings. Intussusception reduction after the first enema attempt occurred in 75% (MDZ group) and 32.4% (non-MDZ group) of patients (P < .001); 27.9% (MDZ group) and 77.8% (non-MDZ group) of patients underwent surgery (P < .001). Among them, spontaneous reduction of intussusception during the induction of general anesthesia occurred in 31.6% and 42.9% of patients, respectively (P .43). Multivariate logistic regression analysis showed that only MDZ had a positive effect on the result of the enema (OR 7.602, 95%CI 2.669-21.652, P < .001). CONCLUSION: Procedural sedation with MDZ for enema reduction of intussusception can increase the success rate and lead to a better management of patients. WHAT IS KNOWN: • Despite the evidence of the usefulness of sedatives in the reduction of intussusception, their use is still not a common practice. WHAT IS NEW: • Midazolam during enema reduction of intussusception can increase the success rate and consequently lead to better management of patients.
Ileocolic intussusception is a common cause of bowel obstruction. When spontaneous reduction does not occur, non-operative management through enema reduction is necessary. Despite the evidence indicating that sedatives favor success in the reduction, their use is still not a common practice. To determine if midazolam (MDZ) before enema improves the rate of procedure success, we retrospectively reviewed charts of patients admitted to two Italian pediatric emergency departments. Outcome measures were the success rate of the enema, recurrence, and need for surgery. Patients were grouped according to the use of MDZ or not, before hydrostatic reduction attempt. We included 69 and 37 patients in the MDZ and non-MDZ groups, respectively. The two groups did not differ in demographics, clinical characteristics, and ultrasound findings. Intussusception reduction after the first enema attempt occurred in 75% (MDZ group) and 32.4% (non-MDZ group) of patients (P < .001); 27.9% (MDZ group) and 77.8% (non-MDZ group) of patients underwent surgery (P < .001). Among them, spontaneous reduction of intussusception during the induction of general anesthesia occurred in 31.6% and 42.9% of patients, respectively (P .43). Multivariate logistic regression analysis showed that only MDZ had a positive effect on the result of the enema (OR 7.602, 95%CI 2.669-21.652, P < .001). CONCLUSION: Procedural sedation with MDZ for enema reduction of intussusception can increase the success rate and lead to a better management of patients. WHAT IS KNOWN: • Despite the evidence of the usefulness of sedatives in the reduction of intussusception, their use is still not a common practice. WHAT IS NEW: • Midazolam during enema reduction of intussusception can increase the success rate and consequently lead to better management of patients.
Authors: Jascha A van de Bunt; Esther S Veldhoen; Rutger A J Nievelstein; Caroline C C Hulsker; Antonius N J Schouten; Maud Y A van Herwaarden Journal: Paediatr Anaesth Date: 2017-09-20 Impact factor: 2.556