Literature DB >> 3573045

Palmitate uptake in calcium tolerant, adult rat myocardial single cells--evidence for an albumin mediated transport across sarcolemma.

B Rauch, C Bode, H M Piper, J F Hütter, R Zimmermann, E Braunwell, W Hasselbach, W Kübler.   

Abstract

The dependence of (1-14C)-palmitate uptake in adult rat heart single cells on albumin was investigated. The apparent initial rate of palmitate uptake vs total palmitate concentration exhibited saturation kinetics, provided the concentration ratio of palmitate vs albumin was kept constant. However, if total palmitate was increased at constant albumin concentrations, the dependence of the initial rate on palmitate concentration was linear. Within the concentration range of total palmitate investigated in this study, the concentration of free palmitate remained almost constant. These results favour the hypothesis, that palmitate uptake in rat myocardium may be mediated by an albumin dependent sarcolemmal transport system.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3573045     DOI： 10.1016/s0022-2828(87)80558-8

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


  7 in total

1.  The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation.

Authors:  Christine M Bowman; Hideaki Okochi; Leslie Z Benet
Journal:  Drug Metab Dispos       Date:  2019-01-23       Impact factor: 3.922

2.  Kinetic assessment of apparent facilitation by albumin of cellular uptake of unbound ligands.

Authors:  D J Morgan; C K Stead; R A Smallwood
Journal:  J Pharmacokinet Biopharm       Date:  1990-04

3.  At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.

Authors:  D Sorrentino; R B Robinson; C L Kiang; P D Berk
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808

4.  Effect of plasma protein binding on kinetics of capillary uptake and efflux.

Authors:  D J Morgan; J L Huang
Journal:  Pharm Res       Date:  1993-02       Impact factor: 4.200

5.  Myocardial scintigraphy with iodine-123 phenylpentadecanoic acid and thallium-201 in patients with coronary artery disease: a comparative dual-isotope study.

Authors:  R Zimmermann; B Rauch; M Kapp; B Bubeck; F J Neumann; F Seitz; P Stokstad; G Mall; H Tillmanns; W Kübler
Journal:  Eur J Nucl Med       Date:  1992

6.  Is fatty acid uptake in cardiomyocytes determined by physicochemical fatty acid partition between albumin and membranes?

Authors:  H Rose; T Hennecke; H Kammermeier
Journal:  Mol Cell Biochem       Date:  1989 Jun 27-Jul 24       Impact factor: 3.396

7.  Identification of albumin-binding proteins in capillary endothelial cells.

Authors:  N Ghinea; A Fixman; D Alexandru; D Popov; M Hasu; L Ghitescu; M Eskenasy; M Simionescu; N Simionescu
Journal:  J Cell Biol       Date:  1988-07       Impact factor: 10.539
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.