| Literature DB >> 3572975 |
R N Guthikonda, L D Cama, M Quesada, M F Woods, T N Salzmann, B G Christensen.
Abstract
The labile tert-butyldimethylsilyl esters of the azetidinones 6-8b served as the crucial synthons in the preparation of the potentially useful ylide pyridyl thio esters 18-20. These intermediates were utilized to synthesize a host of title carbapenems 25-30d, 32, and 49-53. The antimicrobial properties and DHP-I susceptibility of these carbapenems were studied with reference to thienamycin.Entities:
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Year: 1987 PMID： 3572975 DOI： 10.1021/jm00388a022
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446