Janine Pöss1, Christoph Sinning2, Guido Michels3, Holger Thiele4, Isabelle Schreiner4, Christian Apfelbacher5, Karl-Philipp Drewitz5, Nadine Hösler6, Steffen Schneider7, Burkert Pieske8, Bernd W Böttiger9, Sebastian Ewen10, Harm Wienbergen11, Malte Kelm12, Daniel Bock13, Tobias Graf14, Christoph Adler9, Jochen Dutzmann15, Wulf Knie16, Martin Orban17, Uwe Zeymer7. 1. Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Strümpellstr. 39, 04289, Leipzig, Germany. janine.poess@medizin.uni-leipzig.de. 2. University Heart and Vascular Center Hamburg, Hamburg, Germany. 3. St.-Antonius-Hospital gGmbH, Eschweiler, Germany. 4. Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Strümpellstr. 39, 04289, Leipzig, Germany. 5. Medical Faculty, Otto Von Guericke University Magdeburg, Magdeburg, Germany. 6. Leipzig Heart Science, Leipzig, Germany. 7. Institut Für Herzinfarktforschung, Ludwigshafen am Rhein, Germany. 8. Charité University Medicine, Campus Virchow Klinikum and German Heart Center and Berlin Brandenburger Center for Regenerative Therapies (BCRT) of the Berlin Institute of Health (BIH), Berlin, Germany. 9. Faculty of Medicine and University Hospital Cologne, Cologne, Germany. 10. University Hospital Saarland, Homburg/Saar, Germany. 11. Klinikum Links Der Weser, Bremen, Germany. 12. University Hospital Düsseldorf, Düsseldorf, Germany. 13. Klinikum Frankfurt Höchst GmbH, Frankfurt am Main, Germany. 14. University Heart Center Lübeck, Lübeck, Germany. 15. University Hospital Halle (Saale), Halle, Germany. 16. Charité University Medicine, Campus Benjamin Franklin, Berlin, Germany. 17. Klinikum der Universität München and DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Abstract
BACKGROUND: In Germany, 70,000-100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence from randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course and of the outcome of OHCA patients is warranted. STUDY DESIGN: The German Cardiac Arrest Registry (G-CAR) is an observational, prospective, multicentre registry. It will determine the characteristics, initial treatment strategies, invasive procedures, revascularisation therapies and the use of mechanical circulatory support devices with a focus on extracorporeal cardiopulmonary resuscitation. A special feature is the prospective 12-month follow-up evaluating mortality, neurological outcomes and several patient-reported outcomes in the psychosocial domain (health-related quality of life, cognitive impairment, depression/anxiety, post-traumatic stress disorder and social reintegration). In a pilot phase of 24 months, 15 centres will include approximately 400 consecutive OHCA patients ≥ 18 years. Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged. CONCLUSION: G-CAR is the first national registry including a long-term follow-up for adult OHCA patients. Primary aim is a better understanding of the determinants of acute and long-term outcomes with the perspective of an optimised treatment. TRIAL REGISTRY: NCT05142124. German Cardiac Arrest Registry (G-CAR).
BACKGROUND: In Germany, 70,000-100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence from randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course and of the outcome of OHCA patients is warranted. STUDY DESIGN: The German Cardiac Arrest Registry (G-CAR) is an observational, prospective, multicentre registry. It will determine the characteristics, initial treatment strategies, invasive procedures, revascularisation therapies and the use of mechanical circulatory support devices with a focus on extracorporeal cardiopulmonary resuscitation. A special feature is the prospective 12-month follow-up evaluating mortality, neurological outcomes and several patient-reported outcomes in the psychosocial domain (health-related quality of life, cognitive impairment, depression/anxiety, post-traumatic stress disorder and social reintegration). In a pilot phase of 24 months, 15 centres will include approximately 400 consecutive OHCA patients ≥ 18 years. Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged. CONCLUSION: G-CAR is the first national registry including a long-term follow-up for adult OHCA patients. Primary aim is a better understanding of the determinants of acute and long-term outcomes with the perspective of an optimised treatment. TRIAL REGISTRY: NCT05142124. German Cardiac Arrest Registry (G-CAR).
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