Editor,We would like to share ideas on the publication “Relapse of minimal change disease after inactivated SARS-CoV-2 vaccination: case report [1].” Özkan, et al. noted that “We describe a case of MCD relapse after a second dose of inactive that patients should be informed accordingly [1].” We agree that COVID-19 vaccine can cause clinical problem including renal disorder. The present case might or might not be the result of COVID-19 vaccine. There is no pre-vaccination data on immune/renal status of the patient. It is difficult to conclude on any interrelationship. The possibility that the relapse is due to the background medical problem or concurrent medical disorder should be kept in mind. For example, after vaccination, the vaccine recipient might experience concurrent arbovirus infection [2]. The arbovirus infection is a rare but possible cause of minimal change disease [3].