| Literature DB >> 35726077 |
Miranda Zuniga-Kennedy1,2,3, Micah Davoren1,2,3, Lauren C Shuffrey1,2, Ruth Ann Luna4,5, Tor Savidge4,5, Vinay Prasad6, George M Anderson7, Jeremy Veenstra-VanderWeele8,9,10,11, Kent C Williams12.
Abstract
Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT.Entities:
Keywords: Autism; Hyperserotonemia; Immunity; Whole blood serotonin
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Year: 2022 PMID： 35726077 DOI： 10.1007/s10803-022-05597-w
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257