Shangpei Wang1,2,3, Tong Wu4, Chuan Li4, Tieyu Wu4, Yinfeng Qian1,2,3, Cuiping Ren4,5, Yan Qin4, Juan Li4, Xianzhou Chu4, Xianwen Chen6, Yongqiang Yu7,8,9. 1. Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. 2. Research Center of Clinical Medical Imaging, Anhui Province, Hefei, 230032, China. 3. Anhui Provincial Institute of Translational Medicine, Hefei, 230032, China. 4. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. 5. Department of Emergency, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. 6. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. chxwmail@aliyun.com. 7. Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. cjr.yuyongqiang@vip.163.com. 8. Research Center of Clinical Medical Imaging, Anhui Province, Hefei, 230032, China. cjr.yuyongqiang@vip.163.com. 9. Anhui Provincial Institute of Translational Medicine, Hefei, 230032, China. cjr.yuyongqiang@vip.163.com.
Abstract
BACKGROUND: Freezing of gait (FOG) have been associated with deficits in the cortico-basal ganglia-thalamic network. However, the resting-state cerebral blood flow (CBF) alterations specific to FOG in Parkinson's disease (PD) remain unknown. METHODS: In total, sixty PD individuals, including 30 PD with FOG (PD-FOG) and 30 PD without FOG (PD-NFOG), and 30 healthy controls (HC) underwent arterial spin labeling magnetic resonance image. The CBF were voxel-wise compared among the three groups and validated in a different cohort of PD-FOG and PD-NFOG. RESULTS: The results revealed that patients with PD-FOG had increased CBF in bilateral thalamus and the left caudate nucleus and decreased CBF in the left inferior parietal cortex compared to patients with PD-NFOG. The inter-group differences of CBF between PD-FOG and PD-NFOG was confirmed in a different cohort in the validation analysis. Moreover, the CBF in left caudate nucleus was positively correlated with severity of FOG in PD-FOG patients. CONCLUSIONS: Perfusion alterations in both cortical and subcortical regions in the cortico-basal ganglia-thalamic network are related to the development of FOG in PD patients.
BACKGROUND: Freezing of gait (FOG) have been associated with deficits in the cortico-basal ganglia-thalamic network. However, the resting-state cerebral blood flow (CBF) alterations specific to FOG in Parkinson's disease (PD) remain unknown. METHODS: In total, sixty PD individuals, including 30 PD with FOG (PD-FOG) and 30 PD without FOG (PD-NFOG), and 30 healthy controls (HC) underwent arterial spin labeling magnetic resonance image. The CBF were voxel-wise compared among the three groups and validated in a different cohort of PD-FOG and PD-NFOG. RESULTS: The results revealed that patients with PD-FOG had increased CBF in bilateral thalamus and the left caudate nucleus and decreased CBF in the left inferior parietal cortex compared to patients with PD-NFOG. The inter-group differences of CBF between PD-FOG and PD-NFOG was confirmed in a different cohort in the validation analysis. Moreover, the CBF in left caudate nucleus was positively correlated with severity of FOG in PD-FOG patients. CONCLUSIONS: Perfusion alterations in both cortical and subcortical regions in the cortico-basal ganglia-thalamic network are related to the development of FOG in PD patients.
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