Literature DB >> 3572535

Skeletal localization of samarium-153 chelates: potential therapeutic bone agents.

W F Goeckeler, B Edwards, W A Volkert, R A Holmes, J Simon, D Wilson.   

Abstract

A series of stable complexes of 153Sm has been produced using multidentate acetate and phosphonate ligands. Biodistribution studies in unanesthetized rats showed varying degrees of bone and soft-tissue uptake for these complexes. Of the complexes studied, [153Sm] ethylenediaminetetramethylenephosphonate (EDTMP) showed the best combination of high bone uptake, low nonosseous uptake, and rapid blood clearance which warranted its further investigation in rabbits. Rabbit studies confirmed the [153Sm]EDTMP results obtained in rats. Blood clearance in rabbits was found to be more rapid than [99mTc] methylene diphosphonate (MDP). Scintigraphic images were virtually indistinguishable from [99mTc]MDP images. Lesion/normal bone ratios were determined from digitized images obtained using a drill hole model and found to be approximately 17:1. Based on these excellent biodistribution characteristics, [153Sm] EDTMP could be therapeutically useful in treating metastatic bone cancer.

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Year:  1987        PMID： 3572535

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  30 in total

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4.  Modeling the time dependent biodistribution of Samarium-153 ethylenediamine tetramethylene phosphonate using compartmental analysis.

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Review 5.  Strategies for management of prostate cancer-related bone pain.

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8.  Biospeciation, by potentiometry and computer simulation, of Sm-EDTMP, a bone tumor palliative agent.

Authors:  G Charmaine de Witt; P M May; J Webb; G Hefter
Journal:  Biometals       Date:  1996-10       Impact factor: 2.949

9.  Controlled size and morphology of EDTMP-doped hydroxyapatite nanoparticles as model for 153Samarium-EDTMP doping.

Authors:  Yuling Jamie Han; Say Chye Joachim Loo; Ngoc Thao Phung; Hooi Tin Ong; Stephen J Russell; Kah-Whye Peng; Freddy Boey; Jan Ma
Journal:  J Mater Sci Mater Med       Date:  2008-03-25       Impact factor: 3.896

10.  The Level of Europium-154 Contaminating Samarium-153-EDTMP Activates the Radiation Alarm System at the US Homeland Security Checkpoints.

Authors:  Mohammed Najeeb Al Hallak; Matt McCurdy; Nicolas Zouain; Justin Hayes
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