Literature DB >> 3572397

Specificity of ethylcholine mustard aziridinium as an irreversible inhibitor of choline transport in cholinergic and noncholinergic tissue.

J B Uney, R M Marchbanks.   

Abstract

The sensitivity of choline transport to inhibition by ethylcholine mustard aziridinium (ECMA) was studied in several tissues. Choline transport was found to be inhibited irreversibly by ECMA in guinea pig and rat synaptosomes but not inhibited in erythrocytes or kidney slices. If this finding can be extended to other tissues ECMA sensitivity may provide a simple criterion for identifying the choline carrier associated with cholinergic tissue.

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Year:  1987        PMID： 3572397     DOI： 10.1111/j.1471-4159.1987.tb05722.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  4 in total

1.  Selective neurotoxins, chemical tools to probe the mind: the first thirty years and beyond.

Authors:  R M Kostrzewa
Journal:  Neurotox Res       Date:  1999-09       Impact factor: 3.911

2.  Solubilization and partial characterization of [3H]choline mustard-labeled high-affinity choline carrier from presynaptic plasma membrane of Torpedo electric organ.

Authors:  R J Rylett
Journal:  J Mol Neurosci       Date:  1990       Impact factor: 3.444

3.  Effects of AF64A on gene expression of choline acetyltransferase (ChAT) in the septo-hippocampal pathway and striatum in vivo.

Authors:  Q I Fan; I Hanin
Journal:  Neurochem Res       Date:  1999-01       Impact factor: 3.996

Review 4.  Functional regulation of choline acetyltransferase by phosphorylation.

Authors:  Tomas Dobransky; R Jane Rylett
Journal:  Neurochem Res       Date:  2003-04       Impact factor: 3.996
  4 in total

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