Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Sequence analysis of the haemagglutinin of A/Taiwan/1/86, a new variant of human influenza A(H1N1) virus.

Literature DB >> 3572359

Sequence analysis of the haemagglutinin of A/Taiwan/1/86, a new variant of human influenza A(H1N1) virus.

Abstract

A/Taiwan/1/86 is representative of newly emerged antigenic variants of influenza A(H1N1) viruses which are readily distinguishable from all previous A(H1N1) isolates. Nucleotide sequence analysis of the haemagglutinin HA1 coding region of A/Taiwan/1/86 suggests that this virus has evolved from viruses circulating in the Hong Kong region in 1982 to 1983. The considerable alteration in antigenicity of this new isolate is likely to have arisen from five amino acid substitutions in a nine amino acid stretch, situated on the outer surface of a short alpha-helix on the tip of the HA molecule in antigenic site Sb.

Entities: Chemical Species

Mesh：

Substances：

Year: 1987 PMID： 3572359 DOI： 10.1099/0022-1317-68-4-1205

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

Keyword Cloud
Cited

18 in total

1. Genetic relationship between the HA genes of type A influenza viruses isolated in off-seasons and later epidemic seasons.

Authors: S Nakajima; K Nakamura; F Nishikawa; K Nakajima
Journal: Epidemiol Infect Date: 1991-04 Impact factor: 2.451

2. Failure of influenza vaccine to prevent two successive outbreaks of influenza A H1N1 in a school community.

Authors: E L Teare; J C Rawes; P Chakraverty; N D Noah; D Webster; T Corcoran; J Oxford
Journal: Br J Gen Pract Date: 1990-01 Impact factor: 5.386

3. An analysis of the properties of monoclonal antibodies directed to epitopes on influenza virus hemagglutinin.

Authors: L E Brown; J M Murray; D O White; D C Jackson
Journal: Arch Virol Date: 1990 Impact factor: 2.574

4. Generation of live attenuated novel influenza virus A/California/7/09 (H1N1) vaccines with high yield in embryonated chicken eggs.

Authors: Zhongying Chen; Weijia Wang; Helen Zhou; Amorsolo L Suguitan; Cindy Shambaugh; Lomi Kim; Jackie Zhao; George Kemble; Hong Jin
Journal: J Virol Date: 2010-01 Impact factor: 5.103

10. The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic.

Authors: Edwin D Kilbourne; Catherine Smith; Ian Brett; Barbara A Pokorny; Bert Johansson; Nancy Cox
Journal: Proc Natl Acad Sci U S A Date: 2002-07-22 Impact factor: 11.205

Sequence analysis of the haemagglutinin of A/Taiwan/1/86, a new variant of human influenza A(H1N1) virus.

1. Genetic relationship between the HA genes of type A influenza viruses isolated in off-seasons and later epidemic seasons.

2. Failure of influenza vaccine to prevent two successive outbreaks of influenza A H1N1 in a school community.

3. An analysis of the properties of monoclonal antibodies directed to epitopes on influenza virus hemagglutinin.

4. Generation of live attenuated novel influenza virus A/California/7/09 (H1N1) vaccines with high yield in embryonated chicken eggs.

Review 5. Plant-derived virus-like particles as vaccines.

6. Genetic variants of influenza A/Taiwan/1/86 cocirculating in Canada during the winter of 1986 to 1987.

7. Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses.

8. Sequence of an influenza virus hemagglutinin determined directly from a clinical sample.

9. Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus.

10. The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic.