Current update on the protective effect of naringin in inflammatory lung diseases.



Understanding the role of inflammation in developing respiratory illnesses such as COPD, asthma, and lung cancer, is critical. Natural cures are regaining favor as effective treatments for various ailments (Heidary Moghaddam et al., 2020[14]). A flavanone glycoside named naringin (NAR) is found in aromatic Chinese herbal treatments and citrus fruits. Even though several biological and pharmacological properties of NAR have been found via study, only a few systematic reviews have been published (Wadhwa et al., 2021[29]). However, there is a scarcity of studies focusing on NAR's therapeutic potential in respiratory system inflammation. NAR's alleged anti-inflammatory properties influence many pro-inflammatory cytokines, including the NF-κB, ERK1/2, and p38 MAPK pathways in the pathophysiological processes associated with chronic respiratory disorders (Chen et al., 2016[8]). This review will be very useful to researchers in this field. It will take them in a new direction in their hunt for innovative medications to treat respiratory illnesses (Table 1(Tab. 1); References in Table 1: Ahmad et al., 2015[1]; Akintunde et al., 2020[2]; Ali et al., 2017[3]; Bear and Teel, 2000[4]; Cerkezkayabekir et al., 2017[5]; Chang et al., 2017[6]; Chen et al., 2013[9], 2014[10], 2018[7]; Clementi et al., 2021[11]; Fouad et al., 2016[12]; Guihua et al., 2016[13]; Hsiao et al., 2007[15]; Jiao et al., 2015[16]; Kim et al., 2018[17]; Liu et al., 2011[20], 2012[19], 2018[18]; Luo et al., 2012[21]; Nie et al., 2012[22]; Schwarz et al., 2005[23]; Seyedrezazadeh et al., 2015[24]; Shi et al., 2014[27], 2019[25], 2021[26]; Turgut et al., 2016[28]; Wang et al., 2016[30]; Wu et al., 2021[31]; Yao et al., 2021[32]; Zhang et al., 2013[33]).

Table 1

An update on the protective effect of naringin in various inflammatory lung diseases

Conflict of interest

The authors declare no conflict of interest.