Mona Sohrabi1, Bijayani Sahu1, Harpreet Kaur1, Wendie A Hasler1, Atish Prakash1, Colin K Combs1.
Abstract
BACKGROUND: There is a well-described mechanism of communication between the brain and gastrointestinal system in which both organs influence the function of the other. This bi-directional communication suggests that disease in either organ may affect function in the other.
OBJECTIVE: To assess whether the evidence supports gastrointestinal system inflammatory or degenerative pathophysiology as a characteristic of Alzheimer's disease (AD).
METHODS: A review of both rodent and human studies implicating gastrointestinal changes in AD was performed.
RESULTS: Numerous studies indicate that AD changes are not unique to the brain but also occur at various levels of the gastrointestinal tract involving both immune and neuronal changes. In addition, it appears that numerous conditions and diseases affecting regions of the tract may communicate to the brain to influence disease.
CONCLUSION: Gastrointestinal changes represent an overlooked aspect of AD, representing a more system influence of this disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: There is a well-described mechanism of communication between the brain and gastrointestinal system in which both organs influence the function of the other. This bi-directional communication suggests that disease in either organ may affect function in the other.
OBJECTIVE: To assess whether the evidence supports gastrointestinal system inflammatory or degenerative pathophysiology as a characteristic of Alzheimer's disease (AD).
METHODS: A review of both rodent and human studies implicating gastrointestinal changes in AD was performed.
RESULTS: Numerous studies indicate that AD changes are not unique to the brain but also occur at various levels of the gastrointestinal tract involving both immune and neuronal changes. In addition, it appears that numerous conditions and diseases affecting regions of the tract may communicate to the brain to influence disease.
CONCLUSION: Gastrointestinal changes represent an overlooked aspect of AD, representing a more system influence of this disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities:
Keywords:
Alzheimer; Microbiome; amyloid; enteric neuron; inflammation; intestine
Mesh：
Year: 2022
PMID： 35718965 DOI： 10.2174/1567205019666220617121255
Source DB: PubMed Journal: Curr Alzheimer Res ISSN： 1567-2050 Impact factor: 3.040