Literature DB >> 35718411

Therapy-Related Clonal Hematopoiesis: A New Link Between Cancer and Cardiovascular Disease.

Yoshimitsu Yura1, Jesse D Cochran2, Kenneth Walsh3.   

Abstract

Clonal hematopoiesis is a precancerous state that is recognized as a new causal risk factor for cardiovascular disease. Therapy-related clonal hematopoiesis is a condition that is often found in cancer survivors. These clonal expansions are caused by mutations in DNA damage-response pathway genes that allow hematopoietic stem cells to undergo positive selection in response to the genotoxic stress. These mutant cells increasingly give rise to progeny leukocytes that display enhanced proinflammatory properties. Recent experimental studies suggest that therapy-related clonal hematopoiesis may contribute to the medium- to long-term risk of genotoxic therapies on the cardiovascular system.
Copyright © 2022 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cardio-oncology; Clonal hematopoiesis; Inflammation

Mesh：

Year:  2022        PMID： 35718411      PMCID： PMC9219036          DOI： 10.1016/j.hfc.2022.02.010

Source DB:  PubMed          Journal:  Heart Fail Clin        ISSN： 1551-7136            Impact factor:   2.828


  65 in total

1.  Aging as a driver of leukemogenesis.

Authors:  Thomas McKerrell; George S Vassiliou
Journal:  Sci Transl Med       Date:  2015-09-23       Impact factor: 17.956

2.  Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated With Increased Mortality in Patients With Chronic Heart Failure.

Authors:  Sebastian Cremer; Klara Kirschbaum; Alexander Berkowitsch; David John; Katharina Kiefer; Lena Dorsheimer; Julian Wagner; Tina Rasper; Khalil Abou-El-Ardat; Birgit Assmus; Hubert Serve; Michael Rieger; Stefanie Dimmeler; Andreas M Zeiher
Journal:  Circ Genom Precis Med       Date:  2020-06-29

3.  Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.

Authors:  Ryunosuke Saiki; Yukihide Momozawa; Yasuhito Nannya; Masahiro M Nakagawa; Yotaro Ochi; Tetsuichi Yoshizato; Chikashi Terao; Yutaka Kuroda; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Atsushi Niida; Seiya Imoto; Koichi Matsuda; Takayuki Morisaki; Yoshinori Murakami; Yoichiro Kamatani; Shuichi Matsuda; Michiaki Kubo; Satoru Miyano; Hideki Makishima; Seishi Ogawa
Journal:  Nat Med       Date:  2021-07-08       Impact factor: 53.440

4.  The evolutionary dynamics and fitness landscape of clonal hematopoiesis.

Authors:  Caroline J Watson; A L Papula; Gladys Y P Poon; Wing H Wong; Andrew L Young; Todd E Druley; Daniel S Fisher; Jamie R Blundell
Journal:  Science       Date:  2020-03-27       Impact factor: 47.728

Review 5.  The NLRP3 inflammasome: molecular activation and regulation to therapeutics.

Authors:  Karen V Swanson; Meng Deng; Jenny P-Y Ting
Journal:  Nat Rev Immunol       Date:  2019-08       Impact factor: 53.106

6.  Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.

Authors:  Daniel Nachun; Ake T Lu; Alexander G Bick; Pradeep Natarajan; Joshua Weinstock; Mindy D Szeto; Sekar Kathiresan; Goncalo Abecasis; Kent D Taylor; Xiuqing Guo; Russ Tracy; Peter Durda; Yongmei Liu; Craig Johnson; Stephen S Rich; David Van Den Berg; Cecilia Laurie; Tom Blackwell; George J Papanicolaou; Adolfo Correa; Laura M Raffield; Andrew D Johnson; Joanne Murabito; JoAnn E Manson; Pinkal Desai; Charles Kooperberg; Themistocles L Assimes; Daniel Levy; Jerome I Rotter; Alex P Reiner; Eric A Whitsel; James G Wilson; Steve Horvath; Siddhartha Jaiswal
Journal:  Aging Cell       Date:  2021-05-29       Impact factor: 9.304

7.  Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy.

Authors:  Peter G Miller; Adam S Sperling; Elliott J Brea; Mark B Leick; Geoffrey G Fell; Max Jan; Satyen H Gohil; Yu-Tzu Tai; Nikhil C Munshi; Catherine J Wu; Donna S Neuberg; Marcela V Maus; Caron Jacobson; Christopher J Gibson; Benjamin L Ebert
Journal:  Blood Adv       Date:  2021-08-10

8.  PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

Authors:  Joanne I Hsu; Tajhal Dayaram; Ayala Tovy; Etienne De Braekeleer; Mira Jeong; Feng Wang; Jianhua Zhang; Timothy P Heffernan; Sonal Gera; Jeffrey J Kovacs; Joseph R Marszalek; Christopher Bristow; Yuanqing Yan; Guillermo Garcia-Manero; Hagop Kantarjian; George Vassiliou; P Andrew Futreal; Lawrence A Donehower; Koichi Takahashi; Margaret A Goodell
Journal:  Cell Stem Cell       Date:  2018-11-01       Impact factor: 24.633

9.  Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations.

Authors:  Po-Ru Loh; Giulio Genovese; Robert E Handsaker; Hilary K Finucane; Yakir A Reshef; Pier Francesco Palamara; Brenda M Birmann; Michael E Talkowski; Samuel F Bakhoum; Steven A McCarroll; Alkes L Price
Journal:  Nature       Date:  2018-07-11       Impact factor: 49.962

10.  Cancer therapy shapes the fitness landscape of clonal hematopoiesis.

Authors:  Ryan N Ptashkin; Teng Gao; Ahmet Zehir; Elli Papaemmanuil; Kelly L Bolton; Lior Braunstein; Sean M Devlin; Daniel Kelly; Minal Patel; Antonin Berthon; Aijazuddin Syed; Mariko Yabe; Catherine C Coombs; Nicole M Caltabellotta; Mike Walsh; Kenneth Offit; Zsofia Stadler; Diana Mandelker; Jessica Schulman; Akshar Patel; John Philip; Elsa Bernard; Gunes Gundem; Juan E Arango Ossa; Max Levine; Juan S Medina Martinez; Noushin Farnoud; Dominik Glodzik; Sonya Li; Mark E Robson; Choonsik Lee; Paul D P Pharoah; Konrad H Stopsack; Barbara Spitzer; Simon Mantha; James Fagin; Laura Boucai; Christopher J Gibson; Benjamin L Ebert; Andrew L Young; Todd Druley; Koichi Takahashi; Nancy Gillis; Markus Ball; Eric Padron; David M Hyman; Jose Baselga; Larry Norton; Stuart Gardos; Virginia M Klimek; Howard Scher; Dean Bajorin; Eder Paraiso; Ryma Benayed; Maria E Arcila; Marc Ladanyi; David B Solit; Michael F Berger; Martin Tallman; Montserrat Garcia-Closas; Nilanjan Chatterjee; Luis A Diaz; Ross L Levine; Lindsay M Morton
Journal:  Nat Genet       Date:  2020-10-26       Impact factor: 41.307
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