Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Vitamin D binding protein sequesters monomeric actin in the circulation of the rat.

Literature DB >> 3571491

Vitamin D binding protein sequesters monomeric actin in the circulation of the rat.

K D Harper, J F McLeod, M A Kowalski, J G Haddad.

Abstract

Plasma vitamin D binding protein (DBP) may scavenge actin released during cell lysis. We examined the plasma disappearance and tissue appearance of 125I-DBP, 125I-G-actin, and the DBP-G-actin complex after their intravenous administration to rats. The plasma disappearance of DBP and DBP-actin were indistinguishable, with rapid initial (t1/2 = 2.6 h) and slower second (t1/2 = 7 h) slopes. After 125I-G-actin (nanomole) injection, plasma disappearance paralleled that of DBP and DBP-actin. All injected actin was associated with DBP, without evidence of free actin, actin-gelsolin complexes or actin oligomers. Tissue appearances of 125I-apo-DBP (apo) or holo-DBP were similar, with highest accumulations in perfused liver, kidney, and skeletal muscle. Although more complex phenomena (plasma entry of F-actin and intracellular actin binding proteins) would occur in vivo after cell lysis, our results suggest a role for DBP in the sequestration and disposition of actin monomers in the circulation.

Entities: Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3571491 PMCID： PMC424390 DOI： 10.1172/JCI112963

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

34 in total

1. Effects of semi-dilute actin solutions on the mobility of fibrin protofibrils during clot formation.

Authors: P A Janmey; S E Lind; H L Yin; T P Stossel
Journal: Biochim Biophys Acta Date: 1985-08-16

2. Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation.

Authors: S E Lind; D B Smith; P A Janmey; T P Stossel
Journal: J Clin Invest Date: 1986-09 Impact factor: 14.808

3. Sequential binding of actin monomers to plasma gelsolin and its inhibition by vitamin D-binding protein.

Authors: P A Janmey; T P Stossel; S E Lind
Journal: Biochem Biophys Res Commun Date: 1986-04-14 Impact factor: 3.575

4. Characterization of a monoclonal antibody to human serum vitamin D binding protein (Gc globulin): recognition of an epitope hidden in membranes of circulating monocytes.

Authors: J F McLeod; M A Kowalski; J G Haddad
Journal: Endocrinology Date: 1986-07 Impact factor: 4.736

5. Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors: G Mancini; A O Carbonara; J F Heremans
Journal: Immunochemistry Date: 1965-09

6. Evidence of increased Gc:actin complexes in pregnant serum: a possible result of trophoblast embolism.

Authors: D L Emerson; P Arnaud; R M Galbraith
Journal: Am J Reprod Immunol Date: 1983-12 Impact factor: 3.886

7. Enzymatic radioiodination of gonadotropins.

Authors: Y Miyachi; J L Vaitukaitis; E Nieschlag; M B Lipsett
Journal: J Clin Endocrinol Metab Date: 1972-01 Impact factor: 5.958

8. Actin affinity chromatography in the purification of human, avian and other mammalian plasma proteins binding vitamin D and its metabolites (Gc globulins).

Authors: J G Haddad; M A Kowalski; J W Sanger
Journal: Biochem J Date: 1984-03-15 Impact factor: 3.857

9. Brevin and vitamin D binding protein: comparison of the effects of two serum proteins on actin assembly and disassembly.

Authors: A Lees; J G Haddad; S Lin
Journal: Biochemistry Date: 1984-06-19 Impact factor: 3.162

10. Decreased serum group-specific component protein levels and complexes with actin in fulminant hepatic necrosis.

Authors: W M Lee; D L Emerson; P A Werner; P Arnaud; P Goldschmidt-Clermont; R M Galbraith
Journal: Hepatology Date: 1985 Mar-Apr Impact factor: 17.425

11 in total

1. Plasma gelsolin accumulates in macrophage nodules in brains of simian immunodeficiency virus infected rhesus macaques.

Authors: T Jagadish; G Pottiez; H S Fox; P Ciborowski
Journal: J Neurovirol Date: 2012-03-09 Impact factor: 2.643

2. Uptake and degradation of filamentous actin and vitamin D-binding protein in the rat.

Authors: S Dueland; M S Nenseter; C A Drevon
Journal: Biochem J Date: 1991-02-15 Impact factor: 3.857

3. Circulating actin-gelsolin complexes following oleic acid-induced lung injury.

Authors: D B Smith; P A Janmey; S E Lind
Journal: Am J Pathol Date: 1988-02 Impact factor: 4.307

4. Role of group-specific component (vitamin D binding protein) in clearance of actin from the circulation in the rabbit.

Authors: P J Goldschmidt-Clermont; H Van Baelen; R Bouillon; T E Shook; M H Williams; A E Nel; R M Galbraith
Journal: J Clin Invest Date: 1988-05 Impact factor: 14.808

5. Uptake and degradation of vitamin D binding protein and vitamin D binding protein-actin complex in vivo in the rat.

Authors: S Dueland; R Blomhoff; J I Pedersen
Journal: Biochem J Date: 1990-05-01 Impact factor: 3.857

6. Angiopathic consequences of saturating the plasma scavenger system for actin.

Authors: J G Haddad; K D Harper; M Guoth; G G Pietra; J W Sanger
Journal: Proc Natl Acad Sci U S A Date: 1990-02 Impact factor: 11.205

7. Vitamin D-binding protein deficiency in mice decreases systemic and select tissue levels of inflammatory cytokines in a murine model of acute muscle injury.

Authors: Richard R Kew; Tahmineh Tabrizian; James A Vosswinkel; James E Davis; Randeep S Jawa
Journal: J Trauma Acute Care Surg Date: 2018-06 Impact factor: 3.313

8. Definition of the EGTA-independent interface involved in the serum gelsolin-actin complex.

Authors: J Feinberg; J P Capony; Y Benyamin; C Roustan
Journal: Biochem J Date: 1993-08-01 Impact factor: 3.857

9. Circulating complexes of the vitamin D binding protein with G-actin induce lung inflammation by targeting endothelial cells.

Authors: Lingyin Ge; Glenda Trujillo; Edmund J Miller; Richard R Kew
Journal: Immunobiology Date: 2013-10-14 Impact factor: 3.144

10. Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children.

Authors: K M Palframan; S L Robinson; M Mora-Plazas; C Marin; E Villamor
Journal: Epidemiol Infect Date: 2018-07-30 Impact factor: 4.434