| Literature DB >> 35714591 |
Digant Nayak1, Elizabeth V Wasmuth1, Shaun K Olsen2.
Abstract
In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.Entities:
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Year: 2022 PMID： 35714591 PMCID： PMC9233500 DOI： 10.1016/j.chembiol.2022.05.011
Source DB: PubMed Journal: Cell Chem Biol ISSN： 2451-9448 Impact factor: 9.039