Literature DB >> 3571268

Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2.

J D Lear, W F DeGrado.   

Abstract

Synthetic peptides representing amino acid residues 1-16 and 1-20, a proposed fusogenic region of the HA-2 subunit of influenza virus hemagglutinin, bind to phosphatidylcholine vesicles with submicromolar dissociation constants. The 1-20, but not the 1-16, peptide appears to adopt a helical conformation when bound to vesicles and cooperatively promotes vesicle fusion.

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Year:  1987        PMID： 3571268

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  70 in total

1.  Implicit solvent model studies of the interactions of the influenza hemagglutinin fusion peptide with lipid bilayers.

Authors:  D Bechor; N Ben-Tal
Journal:  Biophys J       Date:  2001-02       Impact factor: 4.033

2.  A host-guest system to study structure-function relationships of membrane fusion peptides.

Authors:  X Han; L K Tamm
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-21       Impact factor: 11.205

3.  Investigation of pathways for the low-pH conformational transition in influenza hemagglutinin.

Authors:  M Madhusoodanan; Themis Lazaridis
Journal:  Biophys J       Date:  2003-03       Impact factor: 4.033

4.  The influenza hemagglutinin fusion domain is an amphipathic helical hairpin that functions by inducing membrane curvature.

Authors:  Sean T Smrt; Adrian W Draney; Justin L Lorieau
Journal:  J Biol Chem       Date:  2014-11-14       Impact factor: 5.157

5.  Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization.

Authors:  Wai Leung Lau; David S Ege; James D Lear; Daniel A Hammer; William F DeGrado
Journal:  Biophys J       Date:  2004-01       Impact factor: 4.033

Review 6.  Peptides in cancer nanomedicine: drug carriers, targeting ligands and protease substrates.

Authors:  Xiao-Xiang Zhang; Henry S Eden; Xiaoyuan Chen
Journal:  J Control Release       Date:  2011-10-26       Impact factor: 9.776

Review 7.  Membrane fusion of enveloped viruses: especially a matter of proteins.

Authors:  D Hoekstra
Journal:  J Bioenerg Biomembr       Date:  1990-04       Impact factor: 2.945

Review 8.  Silk-based delivery systems of bioactive molecules.

Authors:  Keiji Numata; David L Kaplan
Journal:  Adv Drug Deliv Rev       Date:  2010-03-16       Impact factor: 15.470

9.  Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses.

Authors:  J S Remy; A Kichler; V Mordvinov; F Schuber; J P Behr
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

10.  Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin.

Authors:  D A Steinhauer; S A Wharton; J J Skehel; D C Wiley
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103
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