| Literature DB >> 35710983 |
Lauren A Green1,2, Michael R O'Dea1, Camden A Hoover1,2, Dana F DeSantis1,2, Cody J Smith3,4.
Abstract
Microglia are the resident macrophages of the CNS that serve critical roles in brain construction. Although human brains contain microglia by 4 weeks gestation, an understanding of the earliest microglia that seed the brain during its development remains unresolved. Using time-lapse imaging in zebrafish, we discovered a mrc1a+ microglia precursor population that seeds the brain before traditionally described microglia. These early microglia precursors are dependent on lymphatic vasculature that surrounds the brain and are independent of pu1+ yolk sac-derived microglia. Single-cell RNA-sequencing datasets reveal Mrc1+ microglia in the embryonic brains of mice and humans. We then show in zebrafish that these early mrc1a+ microglia precursors preferentially expand during pathophysiological states in development. Taken together, our results identify a critical role of lymphatics in the microglia precursors that seed the early embryonic brain.Entities:
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Year: 2022 PMID： 35710983 DOI： 10.1038/s41593-022-01091-9
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 28.771