Jinrong Hu1, Xing Liu1, Shuai Liu1, Hongfei Sang1, Jiacheng Huang1, Weidong Luo1, Jie Wang2, Zhuo Chen3, Shuang Yang4, Wencheng He5, Bo Zhang6, Zhou Yu7, Shan Wang8, Hongbin Wen9, Xiurong Zhu10, Ruidi Sun1, Jie Yang1, Linyu Li1, Jiaxing Song1, Yan Tian1, Zhongming Qiu11, Fengli Li1,12, Wenjie Zi1,12, Yaoyu Tian13. 1. Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China. 2. Department of Neurology, People's Hospital of Chongqing Banan District, Chongqing, 400037, China. 3. Department of Neurology, Mianzhu Hospital, West China Hospital of Sichuan University, Mianzhu, 618200, China. 4. Department of Neurology, People's Hospital of Zunyi City Bo Zhou District, Zunyi, 563000, China. 5. Department of Neurology, GuiPing People's Hospital, GuiPing, 537200, China. 6. Department of Neurology, Suining First People's Hospital, Suining, 629000, China. 7. Department of Neurology, The First People's Hospital of Liangshan Yi Autonomous Prefecture, Xichang, 615000, China. 8. Department of Neurology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, 400000, China. 9. Department of Neurology, Xiangyang Central Hospital, Hubei Arts and Science University, Xiangyang, 441100, China. 10. Department of Neurology, Chongzhou People's Hospital, Chongzhou, 611200, China. 11. Department of Neurology, The 903th Hospital of The People's Liberation Army, Hangzhou, 310007, China. 12. Department of Neurology, Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, 400064, China. 13. Department of Neurology, Qian Xi Nan People's Hospital, No. B6 Road, Jukang Road, Jushan Office, Xingyi City, 562400, Buyi and Miao Autonomous Prefecture, Qianxinanzhou, China. tiantaoyu123@sina.com.
Abstract
INTRODUCTION: This study aimed to investigate clinical outcomes in young patients with basilar artery occlusion (BAO) receiving endovascular therapy (EVT). METHODS: Consecutive patients with BAO within 24 h who underwent EVT from the BASILAR Registry study were enrolled. We compared clinical outcomes of young patients (aged 18-55 years) with older patients (aged > 55 years) with stroke due to BAO at 90 days and 1 year after EVT. The primary and secondary outcomes were improvement in modified Rankin scale scores (mRS) at 90 days and either favorable (mRS 0-3) or mortality at 90 days, respectively. RESULTS: A total of 646 patients were included, of which 152 (23.53%) were aged 18-55 years. Dyslipidemia (42.11% vs. 30.36%, p = 0.007) and good collateral circulation (60.52% vs. 46.35%, p = 0.002) were more frequent in young patients than older. Stroke etiologies in young patients included large artery atherosclerosis (67.11%), cardioembolism (15.13%), and vessel dissection (5.26%). Young patients were associated with better prognosis (mRS: adjusted odds ratio (aOR) 1.73; 95% confidence interval [CI] 1.21-2.48; mRS 0-3: aOR 1.60; 95% CI 1.01-2.54; mortality: aOR 0.60; 95% CI 0.38-0.93) at 90 days. Baseline National Institutes of Health Stroke Scale (NIHSS) score, posterior circulation Alberta Stroke Program Early Computed Tomography Score (pc-ASPECTS), and sex were independent predictors of clinical outcomes of young patients at 90 days after EVT. CONCLUSION: Young patients with BAO had better clinical outcomes after EVT than old patients. Predictors of clinical outcomes in young patients undergoing EVT included baseline NIHSS score, pc-ASPECTS, and sex. TRIAL REGISTRATION: Clinical Trial Registration-URL: ChiCTR180001475 ( www.chictr.org.cn ).
INTRODUCTION: This study aimed to investigate clinical outcomes in young patients with basilar artery occlusion (BAO) receiving endovascular therapy (EVT). METHODS: Consecutive patients with BAO within 24 h who underwent EVT from the BASILAR Registry study were enrolled. We compared clinical outcomes of young patients (aged 18-55 years) with older patients (aged > 55 years) with stroke due to BAO at 90 days and 1 year after EVT. The primary and secondary outcomes were improvement in modified Rankin scale scores (mRS) at 90 days and either favorable (mRS 0-3) or mortality at 90 days, respectively. RESULTS: A total of 646 patients were included, of which 152 (23.53%) were aged 18-55 years. Dyslipidemia (42.11% vs. 30.36%, p = 0.007) and good collateral circulation (60.52% vs. 46.35%, p = 0.002) were more frequent in young patients than older. Stroke etiologies in young patients included large artery atherosclerosis (67.11%), cardioembolism (15.13%), and vessel dissection (5.26%). Young patients were associated with better prognosis (mRS: adjusted odds ratio (aOR) 1.73; 95% confidence interval [CI] 1.21-2.48; mRS 0-3: aOR 1.60; 95% CI 1.01-2.54; mortality: aOR 0.60; 95% CI 0.38-0.93) at 90 days. Baseline National Institutes of Health Stroke Scale (NIHSS) score, posterior circulation Alberta Stroke Program Early Computed Tomography Score (pc-ASPECTS), and sex were independent predictors of clinical outcomes of young patients at 90 days after EVT. CONCLUSION: Young patients with BAO had better clinical outcomes after EVT than old patients. Predictors of clinical outcomes in young patients undergoing EVT included baseline NIHSS score, pc-ASPECTS, and sex. TRIAL REGISTRATION: Clinical Trial Registration-URL: ChiCTR180001475 ( www.chictr.org.cn ).
Authors: Florian Schöberl; Peter Arthur Ringleb; Reza Wakili; Sven Poli; Frank Arne Wollenweber; Lars Kellert Journal: Dtsch Arztebl Int Date: 2017-08-07 Impact factor: 5.594
Authors: N Yesilot Barlas; J Putaala; U Waje-Andreassen; S Vassilopoulou; K Nardi; C Odier; G Hofgart; S Engelter; A Burow; L Mihalka; M Kloss; J Ferrari; R Lemmens; O Coban; E Haapaniemi; N Maaijwee; L Rutten-Jacobs; A Bersano; C Cereda; P Baron; L Borellini; C Valcarenghi; L Thomassen; A J Grau; F Palm; C Urbanek; R Tuncay; A Durukan Tolvanen; E J van Dijk; F E de Leeuw; V Thijs; S Greisenegger; K Vemmos; C Lichy; D Bereczki; L Csiba; P Michel; D Leys; K Spengos; H Naess; T Tatlisumak; S Z Bahar Journal: Eur J Neurol Date: 2013-07-10 Impact factor: 6.089