Literature DB >> 3570477

Cytotoxicity of Shiga toxin for primary cultures of human colonic and ileal epithelial cells.

M P Moyer, P S Dixon, S W Rothman, J E Brown.   

Abstract

Shiga toxin purified from Shigella dysenteriae 1 was cytotoxic to cultured epithelial cells from human colon and ileum. The cytotoxicity, which affected only about 50% of treated cells, was neutralized by rabbit antiserum monospecific for Shiga toxin and mediated by protein synthesis inhibition.

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Year:  1987        PMID： 3570477      PMCID： PMC260549          DOI： 10.1128/iai.55.6.1533-1535.1987

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  The action of the thermolabile toxin of Shigella dysenteriae on cells cultivated in vitro.

Authors:  G VICARI; A L OLITZKI; Z OLITZKI
Journal:  Br J Exp Pathol       Date:  1960-04

2.  Inhibition of protein synthesis in intact HeLa cells by Shigella dysenteriae 1 toxin.

Authors:  J E Brown; S W Rothman; B P Doctor
Journal:  Infect Immun       Date:  1980-07       Impact factor: 3.441

3.  Interaction of Shigella shigae cytotoxin with receptors on sensitive and insensitive cells.

Authors:  K Eiklid; S Olsnes
Journal:  J Recept Res       Date:  1980

4.  Inhibition of protein synthesis by Shiga toxin: activation of the toxin and inhibition of peptide elongation.

Authors:  J E Brown; M A Ussery; S H Leppla; S W Rothman
Journal:  FEBS Lett       Date:  1980-08-11       Impact factor: 4.124

5.  Characterization of Shigella dysenteriae 1 (Shiga) toxin purified by anti-Shiga toxin affinity chromatography.

Authors:  A D O'Brien; G D LaVeck; D E Griffin; M R Thompson
Journal:  Infect Immun       Date:  1980-10       Impact factor: 3.441

6.  Isolation and characterization of Shigella shigae cytotoxin.

Authors:  S Olsnes; K Eiklid
Journal:  J Biol Chem       Date:  1980-01-10       Impact factor: 5.157

7.  Quantitative microtiter cytotoxicity assay for Shigella toxin.

Authors:  M K Gentry; J M Dalrymple
Journal:  J Clin Microbiol       Date:  1980-09       Impact factor: 5.948

8.  The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I.

Authors:  G T Keusch; G F Grady; L J Mata; J McIver
Journal:  J Clin Invest       Date:  1972-05       Impact factor: 14.808

9.  Subunit structure of Shigella cytotoxin.

Authors:  S Olsnes; R Reisbig; K Eiklid
Journal:  J Biol Chem       Date:  1981-08-25       Impact factor: 5.157

10.  The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit.

Authors:  R Reisbig; S Olsnes; K Eiklid
Journal:  J Biol Chem       Date:  1981-08-25       Impact factor: 5.157
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  9 in total

1.  Shiga toxin 1 from Escherichia coli blocks activation and proliferation of bovine lymphocyte subpopulations in vitro.

Authors:  C Menge; L H Wieler; T Schlapp; G Baljer
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

2.  Serological responses to the B subunit of Shiga-like toxin 1 and its peptide fragments indicate that the B subunit is a vaccine candidate to counter action of the toxin.

Authors:  B Boyd; S Richardson; J Gariepy
Journal:  Infect Immun       Date:  1991-03       Impact factor: 3.441

Review 3.  Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.

Authors:  C L Sears; J B Kaper
Journal:  Microbiol Rev       Date:  1996-03

4.  Role of Shiga toxin in the pathogenesis of bacillary dysentery, studied by using a Tox- mutant of Shigella dysenteriae 1.

Authors:  A Fontaine; J Arondel; P J Sansonetti
Journal:  Infect Immun       Date:  1988-12       Impact factor: 3.441

5.  Direct cytotoxic action of Shiga toxin on human vascular endothelial cells.

Authors:  T G Obrig; P J Del Vecchio; J E Brown; T P Moran; B M Rowland; T K Judge; S W Rothman
Journal:  Infect Immun       Date:  1988-09       Impact factor: 3.441

6.  Physicochemical and biological properties of purified Escherichia coli Shiga-like toxin II variant.

Authors:  D L MacLeod; C L Gyles; A Valdivieso-Garcia; R C Clarke
Journal:  Infect Immun       Date:  1991-04       Impact factor: 3.441

7.  Escherichia coli O157:H7 and O157:H(-) strains that do not produce Shiga toxin: phenotypic and genetic characterization of isolates associated with diarrhea and hemolytic-uremic syndrome.

Authors:  H Schmidt; J Scheef; H I Huppertz; M Frosch; H Karch
Journal:  J Clin Microbiol       Date:  1999-11       Impact factor: 5.948

8.  Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga B-fragment is regulated by butyric acid and cAMP.

Authors:  K Sandvig; M Ryd; O Garred; E Schweda; P K Holm; B van Deurs
Journal:  J Cell Biol       Date:  1994-07       Impact factor: 10.539

9.  Changes in the peripheral blood T-Cell receptor V beta repertoire in vivo and in vitro during shigellosis.

Authors:  D Islam; B Wretlind; A A Lindberg; B Christensson
Journal:  Infect Immun       Date:  1996-04       Impact factor: 3.441
  9 in total

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