Greater neuromuscular fatigue following low-load blood flow restriction than non-blood flow restriction resistance exercise among recreationally active men.

The purpose of this study was to examine the acute effects of low-load blood flow restriction (LLBFR) and low-load non-BFR (LL) on neuromuscular function after a bout of standardized fatiguing leg extension muscle actions. Fourteen men (mean age ± SD = 23 ± 4 yr) volunteered to participate in this investigation and randomly performed LLBFR and LL on separate days. Resistance exercise consisted of 75 isotonic unilateral leg extension muscle actions performed at 30% of one-repetition maximum. Before (pretest) and after (posttest) performance of each bout of exercise, strength and neural assessments were determined. There were no pretest to posttest differences between LLBFR and LL for maximal voluntary isometric contraction (MVIC) torque or V wave/M wave responses (muscle compound action potentials assessed during a superimposed MVIC muscle action), which exhibited decreases (collapsed across condition) of 41.2% and 26.2%, respectively. There were pretest to posttest decreases in peak twitch torque (36.0%) and surface electromyography amplitude (sEMG) (29.5%) for LLBFR but not LL and larger decreases in voluntary activation for LLBFR (11.3%) than for LL (4.5%). These findings suggested that LLBFR elicited greater fatigue-induced decreases in several indexes of neuromuscular function relative to LL. Despite this, both LLBFR and LL resulted in similar decrements in performance as assessed by maximal strength.NEW & NOTEWORTHY The application of blood flow restriction induces greater acute neuromuscular fatigue relative to nonrestricted conditions. Resistance exercise with blood flow restriction elicited a greater reduction in twitch responses. These neuromuscular differences might explain the more favorable adaptations achieved with blood flow restriction that are likely a function of metabolic stress and subsequent changes in efferent neural drive.