The effects of combination therapy by solid lipid nanoparticle and dental stem cells on different degenerative diseases.

Stem cells have multiple therapeutic applications, as well as solid lipid nanoparticles. Solid lipid nanoparticle has appeared as a field of nano lipid technology with various potential applications in drug delivery, clinical medicine and research. Besides, the stem cells have a high proliferation rate and could differentiate into a variety of tissues. Stem cells derived from human dental pulp tissue differ from other sources of mesenchymal stem cells due to their embryonic neural crest source and neurotrophic potential. These consist of both dental pulp stem cells from dental pulp tissues of human permanent teeth and stem cells from human exfoliated deciduous teeth. With the emergence of stem cell banks, stem cells are considering for tissue engineering with respect to therapies attitude and regenerative medicine. The present study aimed to evaluate the advantages and disadvantages of the solid lipid nanoparticle and stem cells combination therapy in different therapeutic applications. The solid lipid nanoparticles have anticancer activity against tumors, induce neural differentiation in pluripotent stem cells, and regulate the mesenchymal stem cells. They also have immunomodulatory effects on human mesenchymal stem cells, the gene transfection efficiency, osteogenic differentiation and bone regeneration. But, the crucial health hazards related to stem cell transplantation such as immune rejection reactions and the interaction with other tissues and the effect of solid lipid nanoparticles must not be neglected. Overall, more experiments need to approve the synergism and antagonism effects of the stem cells and solid lipid nanoparticle combination therapy on different degenerative diseases. AJTR