| Literature DB >> 3569749 |
A Sasa, H Hayashi, A Yagi, S Ohguchi, R Kidokoro, Y Sato, N Sakamoto.
Abstract
An asymptomatic 16-year-old boy was found to have Wilson's disease without Kayser-Fleischer rings. Liver biopsy showed chronic active hepatitis with 1025 micrograms copper/g dry weight. After 19 months of d-penicillamine therapy, the liver histology became almost normal and the copper content decreased to 238 micrograms/g dry weight. The liver specimens obtained before and after treatment were studied by X-ray probe microanalysis. After treatment, both copper and sulfur decreased in hepatocellular lysosomes. The estimated molar ratio of the decreased copper to the decreased sulfur was 32/100. These figures suggest that lysosomal copper exists in the form of metallothionein.Entities:
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Year: 1986 PMID： 3569749 DOI： 10.1007/bf02774493
Source DB: PubMed Journal: Gastroenterol Jpn ISSN： 0435-1339